NAPSIN A (NAPSA) Mouse Monoclonal Antibody [Clone ID: MRQ-60]

Specifications

Product Data
Clone Name	MRQ-60
Applications	IHC
Recommend Dilution	IHC: 1:100 - 1:500
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Formulation	This antibody is supplied as cell culture supernatant diluted in tris buffered saline, pH 7.3-7.7, with 1% BSA and <0.1% sodium azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	napsin A aspartic peptidase
Database Link	NP_004842 Entrez Gene 9476 Human UniProt ID O96009
Synonyms	KAP; Kdap; NAP1; NAPA; SNAPA
Note	Napsin A is a functional aspartic proteinase that is expressed in the normal lung parenchyma in type II pneumocytes and the proximal and convoluted tubules of the kidney. It is present in the lysosomes of type II pneumocytes and alveolar macrophages (probably secondary to phagocytosis) and to a lesser degree in pancreatic acini and ducts. It is expressed in the cytoplasm and is strongly positive in up to 80% of primary lung adenocarcinomas. Squamous cell carcinomas and small cell carcinomas of the lung are characteristically negative for napsin A. Adenocarcinomas including those from the breast, pancreas, biliary tract, and colon rarely stain with anti-napsin A. Pulmonary adenocarcinoma with enteric differentiation (PAED) is a special case in that essentially none of these cases are labeled by napsin A antibody.
Reference Data
Protein Families	Druggable Genome, Protease
Protein Pathways	Lysosome

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