ATIC Mouse Monoclonal Antibody [Clone ID: F38P7H9]

Specifications

Product Data
Clone Name	F38P7H9
Applications	WB
Recommend Dilution	WB
Reactivity	Human, Mouse, Rat, Frog, Fruit fly
Host	Mouse
Clonality	Monoclonal
Immunogen	Ovalbumin-conjugated synthetic Peptide AHTNLRLFHH
Formulation	This antibody is provided in phosphate-buffered solution, pH 7.2, containing 0.09% sodium azide at 0.5 mg/ml.
Concentration	lot specific
Purification	The antibody was purified by affinity chromatography.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	65 kD
Gene Name	5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase
Database Link	NP_004035 Entrez Gene 81643 RatEntrez Gene 108147 MouseEntrez Gene 471 Human UniProt ID P31939
Background	ATIC (AICAR transformylase/IMP cyclohydrolase) belongs to the purH family, expressed in the cytoplasm, predicted molecular weight approximately 65 kD. ATIC catalyzes the penultimate and final steps in the de novo purine nucleotide biosynthesis pathway. ATIC acts as a bifunctional enzyme catalyze the formation of FAICAR and IMP. AICA-ribosiduria is a recently discovered inherited metabolic disease caused by a defect in final steps of purine de novo biosynthesis. Clone F38P7H9 has been shown to be useful for western blotting and immunohistochemistry of human, mouse, rat, frog and fruit fly ATIC.
Synonyms	AICAR; AICARFT; HEL-S-70p; IMPCHASE; PURH
Reference Data
Protein Families	Stem cell - Pluripotency
Protein Pathways	Metabolic pathways, One carbon pool by folate, Purine metabolism

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