alpha Synuclein (SNCA) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 1:500 - 1:2000
Reactivity	Human, Mouse, Rat
Modifications	Phospho-specific
Host	Rabbit
Clonality	Polyclonal
Immunogen	A phospho specific peptide corresponding to residues surrounding S129 of human SNCA
Formulation	Store at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Concentration	lot specific
Purification	Affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	140
Gene Name	synuclein alpha
Database Link	NP_000336 Entrez Gene 20617 MouseEntrez Gene 29219 RatEntrez Gene 6622 Human UniProt ID P37840
Background	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Four alternatively spliced transcripts encoding two different isoforms have been identified for this gene.
Synonyms	NACP; PARK1; PARK4; PD1
Reference Data
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Parkinson's disease

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