Osteoprotegerin (TNFRSF11B) Mouse Monoclonal Antibody [Clone ID: 98A1071]

Specifications

Product Data
Clone Name	98A1071
Applications	CyTOF-ready, ELISA, FC, ICC/IF, IHC, IP, WB
Recommend Dilution	Western Blot: 1 ug/ml, Immunohistochemistry-Paraffin: 1:100-1:1000, Immunohistochemistry: 1:100-1:1000, CyTOF-ready, ELISA, Flow Cytometry: 0.2-1 ug/1 million cells, Immunocytochemistry/ Immunofluorescence: 1:20-1:1000, Immunohistochemistry-Frozen: 1:20-1:1000, Immunoprecipitation: 1:20-1:1000
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	A peptide corresponding to the amino acids 20-37 TQETFPPKYLHYDEETSH of human Osteoprotegerin was used as immunogen for this antibody.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tumor necrosis factor receptor superfamily member 11b
Database Link	NP_002537 Entrez Gene 4982 Human UniProt ID O00300
Background	Osteoprotegerin (OPG) is a secretory glycoprotein belonging to TNF receptor (TNFR) superfamily. As the name implies, it protects bone. Unlike other TNFRs it lacks a transmembrane domain and lacks any apparent cell associated signals. OPG consists of 401 amino acid with molecular mass of approximately 55 kD as a monomer and 110 kD as a disulfide-linked dimer. High levels of OPG mRNA has been detected in lung, heart, kidney, and placenta1. Recombinant OPG blocks osteoclastogenesis in vitro and increases bone density in vivo. Targeted deletion of OPG in mice results in severe early-onset of osteoporosity. These mice also exhibit increase in vascular calcification in the aorta and renal arteries suggesting that it may also play a role in degenerative arterial disease.
Synonyms	OCIF; OPG; TR1
Note	This antibody is useful in Flow Cytometry: 0.2-1 ug/10^6 cells Immunocytochemistry/Immunofluorescence: see Sandra 2006 Immunohistochemistry (frozen): see Boumans 2012 for details. Immunoprecipitation: see Sandra 2006
Reference Data
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction

*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.