TRAIL (TNFSF10) Mouse Monoclonal Antibody [Clone ID: 55B709.3]

Specifications

Product Data
Clone Name	55B709.3
Applications	IHC, WB
Recommend Dilution	Immunohistochemistry, Western Blot: 1-2 ug/ml, Immunohistochemistry-Paraffin: 5 ug/ml
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	This monoclonal antibody was raised against a peptide corresponding to amino acids 17-35 of human TRAIL. This peptide sequence has been shown to be involved in TRAIL and DR5 (TRAIL-R2) interaction.
Formulation	PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Protein G purified
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	tumor necrosis factor superfamily member 10
Database Link	NP_003801 Entrez Gene 8743 Human UniProt ID P50591
Background	Apoptosis, or programmed cell death, occurs during normal cellular differentiation and development of multicellular organisms. Apoptosis is induced by certain cytokines including TNF and Fas ligand in the TNF family through their death domain containing receptors, TNFR1 and Fas. A novel member in the TNF family was recently identified and designated TRAIL (for TNF-related apoptosis-inducing ligand) and Apo-2L (for Apo-2 ligand) (6,7). TRAIL is a type II membrane protein and expressed in a variety of human tissues. Two novel death domain containing receptors DR4 and DR5 have been identified as the receptor for TRAIL3-6. Like TNF and Fas ligand, TRAIL induces apoptosis and NF-kB activation in many tissues and cells.
Synonyms	Apo-2L; APO2L; CD253; TL2; TRAIL
Reference Data
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Apoptosis, Cytokine-cytokine receptor interaction, Natural killer cell mediated cytotoxicity

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