TBK1 Mouse Monoclonal Antibody [Clone ID: 108A429]

CAT#: TA336453

Mouse Monoclonal NAK Antibody (108A429)



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TA336453 is a replacement of AM08296PU-N.

CNY 5,521.00


货期*
5周

规格
    • 100 ug

经常一起买 (4)
Transient overexpression lysate of TANK-binding kinase 1 (TBK1)
    • 100 ug

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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

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Recombinant protein of human TANK-binding kinase 1 (TBK1), 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Recombinant protein of human TANK-binding kinase 1 (TBK1), 100 µg
    • 100 ug

CNY 9,998.00

Specifications

Product Data
Clone Name 108A429
Applications ICC/IF, IHC, IP, WB
Recommend Dilution Immunocytochemistry/ Immunofluorescence: 1:20, Immunohistochemistry: 1:10-1:500, Immunohistochemistry-Paraffin: 1:10-1:500, Western Blot: 1-2 ug/ml, Simple Western: 10 ug/ml, Knockout Validated, Immunoprecipitation
Reactivity Human, Mouse, Rat, Bovine, Canine
Host Mouse
Clonality Monoclonal
Immunogen A synthetic peptide corresponding to amino acids 563-577 (YYQFKKDKAERRLAYC) of human TBK1 was used as immunogen for this antibody (NP_037386).
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name TANK binding kinase 1
Background NF-kB (nuclear factor kB) is sequestered in the cytoplasm by IkB family of inhibitory proteins that mask the nuclear localization signal of NF-kB thereby preventing translocation of NF-kB to the nucleus. External stimuli such as tumor necrosis factor or other cytokines results in phosphorylation and degradation of IkB releasing NF-kB dimers. NF-kB dimer subsequently translocates to the nucleus and activates target genes. Synthesis of IkBa is autoregulated. IkB proteins are phosphorylated by IkB kinase complex consisting of at least three proteins, IKK1/a, IKK2/b, and IKK3/g. IKK1/a and IKK2/b are phosphorylated by NF-kB-inducing kinase (NIK) and MAP kinase kinase kinase-1 (MEKK1), respectively. Recently, a new IKK family member, TBK1 [(TANK-binding kinase), also known as NAK and T2K] has been identified. TANK (TRAF-associated NF-kB activator) interacts with TBK1 and activates NF-kB in a kinase dependent manner.
Synonyms NAK; T2K
Note In Western Blot this antibody detects a band at 80 kDa.
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Cytosolic DNA-sensing pathway, RIG-I-like receptor signaling pathway, Toll-like receptor signaling pathway
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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