Rad9 (RAD9A) Mouse Monoclonal Antibody [Clone ID: 93A535]

CAT#: TA336578

Mouse Monoclonal Rad9 Antibody (93A535)



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CNY 5,381.00


货期*
5周

规格
    • 100 ug

Product images

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Specifications

Product Data
Clone Name 93A535
Applications ICC/IF, IHC, IP, WB
Recommend Dilution Immunocytochemistry/ Immunofluorescence: 1:10-1:500, Immunohistochemistry-Paraffin: 1:10-1:500, Western Blot: 1-2 ug/ml, Immunohistochemistry: 1:10-1:500, Immunoprecipitation: 1:10-1:500
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen The antibody was raised against fusion protein of human full length Rad9.
Formulation PBS containing 0.05% BSA, 0.05% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration lot specific
Purification Protein G purified
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Gene Name RAD9 checkpoint clamp component A
Background Rad9 is a recently isolated human protein that is involved in the control of cell cycle checkpoint. Human Rad9 (hRad9) is homologue of the S. pombe Rad9. Six Rad proteins (Rad1, Rad3, Rad9, Rad17, Rad26, and Hus1) are involved in the early steps of DNA damage check point response in S. pombe. Recently, it has been shown that hRad9 interacts with Bcl-2 family proteins Bcl-2 and Bcl-XL, but not with BAX or BAD. Over-expression of hRad9 in mammalian cells leads to apoptosis, where as antisense Rad9 suppresses cell death induced by DNA damaging agents such as methanosulphonate. Human Rad9 undergoes complex post-translational modifications in undamaged cells and is hyperphosphorylated in response to DNA damage and makes ternary complex with human Rad1 and human HUS1 proteins. This may account for detection of multiple protein bands in some cases by western blot or immunoprecipitation analysis using anti-hRad9 antibody. HRad9 has an intrinsic 3-5 exonuclease activity suggesting that by interaction with DNA it may play a role in the damage-sensing step of the DNA damage checkpoint pathway.
Synonyms RAD9
Note Immunocytochemistry/Immunofluorescence: see Kotmatsu et al. Immunohistochemistry-Paraffin: see Lee et al (2007) for details.
Reference Data
Protein Families Druggable Genome, Stem cell - Pluripotency
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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