Aurora A (AURKA) Mouse Monoclonal Antibody [Clone ID: 1F8]

Specifications

Product Data
Clone Name	1F8
Applications	ELISA, FC, ICC/IF, WB
Recommend Dilution	Flow Cytometry: 1:200-1:400, ELISA: 1:10000, Western Blot: 1:500-1:2000, Immunocytochemistry/ Immunofluorescence: 1:200-1:1000
Reactivity	Human, Rat, Primate
Host	Mouse
Clonality	Monoclonal
Immunogen	Purified recombinant fragment of human Aurora A expressed in E. coli. [UniProt# O14965]
Formulation	PBS, 0.03% Sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Concentration	lot specific
Purification	Ammonium sulfate precipitation
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	48 kDa
Gene Name	aurora kinase A
Database Link	NP_940835 Entrez Gene 261730 RatEntrez Gene 6790 Human UniProt ID O14965
Background	Aurora A plays a role in cell cycle regulation during anaphase and/or telophase, in relation to the function of the centrosome/spindle pole region during chromosome segregation. Aurora A plays a key role during tumor development and progression and is overexpressed in many human cancers including breast, ovarian and colorectal. Aurora A is viewed as a potential target for anticancer drug treatment.Tissue specificity: Highly expressed in testis and weakly in skeletal muscle, thymus and spleen. Also highly expressed in colon, ovarian, prostate, neuroblastoma, breast and cervical cancer cell lines.
Synonyms	AIK; ARK1; AURA; BTAK; PPP1R47; STK6; STK7; STK15
Note	This Aurora A (1F8) antibody is useful for Western blot, Immunocytochemistry/Immunofluorescence, Flow Cytometry and ELISA.
Reference Data
Protein Families	Druggable Genome, Protein Kinase, Stem cell - Pluripotency
Protein Pathways	Oocyte meiosis

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