AGO1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	ELISA, WB
Recommend Dilution	ELISA (1:100); Western blotting (1:1,000)
Reactivity	Human
Host	Rabbit
Clonality	Polyclonal
Immunogen	The immunogen for anti-EF2C1/2 antibody: human IEF2C1/2 (eukaryotic translation initiation factor 2C1 and 2), using a KLH-conjugated synthetic peptide containing a sequence from the C-terminal part of both EIF2C1 and EIF2C2.
Concentration	lot specific
Purification	Whole antiserum from rabbit containing 0.05% azide.
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Gene Name	argonaute 1, RISC catalytic component
Database Link	NP_036331 Entrez Gene 26523 Human UniProt ID Q9UL18
Background	IEF2C1 and 2 (UniProtKB/Swiss-Prot entries Q9UL18 and Q9UKV8) are members of the Argonaute family. These proteins are involved in short-interfering-RNA-mediated gene silencing. This process is mediated by the RISC (RNA induced silencing complex), a multicomponent nuclease that is able to degrade double stranded RNAs. The mRNA degradation is triggered by the association of specific siRNAs with their homologous mRNAs. IEF2C2 has been shown to be essential for embryonic development.
Synonyms	EIF2C; EIF2C1; GERP95; Q99
Reference Data
Protein Families	Druggable Genome

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