Seladin 1 (DHCR24) Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 200-1000 WB positive control: Jurkat and HepG2 cells IHC: 30-150 Positive control: Human breast cancer Predicted cell location: Cytoplasm
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Fusion protein of human DHCR24
Formulation	pH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Concentration	lot specific
Purification	Antigen affinity purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	60 kDa
Gene Name	24-dehydrocholesterol reductase
Database Link	NP_055577 Entrez Gene 74754 MouseEntrez Gene 298298 RatEntrez Gene 1718 Human UniProt ID Q15392
Background	This gene encodes a flavin adenine dinucleotide (FAD)-dependent oxidoreductase which catalyzes the reduction of the delta-24 double bond of sterol intermediates during cholesterol biosynthesis. The protein contains a leader sequence that directs it to the endoplasmic reticulum membrane. Missense mutations in this gene have been associated with desmosterolosis. Also, reduced expression of the gene occurs in the temporal cortex of Alzheimer disease patients and overexpression has been observed in adrenal gland cancer cells.
Synonyms	DCE; Nbla03646; seladin-1; SELADIN1
Reference Data
Protein Families	Druggable Genome, Stem cell - Pluripotency, Transmembrane
Protein Pathways	Metabolic pathways, Steroid biosynthesis

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