SOX1 Rabbit Polyclonal Antibody

Specifications

Product Data
Applications	WB
Recommend Dilution	WB 0.1-1 µg/ml ELISA 0.01-0.1 µg/ml IP 2-5 µg/ml IHC 2-10 µg/ml FC 5-10 µg/ml
Reactivity	Human, Mouse
Host	Rabbit
Clonality	Polyclonal
Immunogen	A synthetic peptide derived from N-terminus of Human SOX-1 protein. This sequence is identical among human and mouse.
Formulation	This affinity purified antibody is supplied in sterile Phosphate buffered saline (pH7.2) containing antibody stabilizer.
Purification	The Rabbit IgG is purified by Epitope Affinity Purification
Conjugation	Unconjugated
Storage Condition	Store at -20°C as received.
Predicted Protein Size	40 kDa
Gene Name	SRY-box 1
Database Link	NP_005977 Entrez Gene 20664 MouseEntrez Gene 6656 Human UniProt ID O00570
Background	The SOX1 is a transcription factor, a member of the SRY-related HMG-box (SOX) family involved in the regulation of embryonic development and in the determination of cell fate. SOX1 is expressed in the developing brain. SOX1 is related to the HMG box of family transcription factors, which are a highly motile group, with a highly conserved DNA binding domain. Sox1 utilizes multiple pathways to play a direct role on cell fate. SOX1 is also directly involved with sex determination of the Y chromosome. Binding of the SOX1, C-terminus, to the Hes 1 promoter results in Hes1 suppression and attenuation of Notch signaling. When the C-terminus of SOX1 binds to β-catenin, TCF/LEF is suppressed, resulting in the attenuation of Wnt signaling.
Synonyms	SRY (sex determining region Y)-box 1; SRY-related HMG-box gene 1
Reference Data
Protein Families	Adult stem cells, ES Cell Differentiation/IPS, Induced pluripotent stem cells, Transmembrane

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