PD1 (PDCD1) Mouse Monoclonal Antibody [Clone ID: 4D6]

CAT#: TA355049

Mouse Monoclonal Anti-PD-1 Antibody [4D6]



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CNY 6,861.00


货期*
5周

规格
    • 100 ug

经常一起买 (3)
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Specifications

Product Data
Clone Name 4D6
Applications ELISA, IF, IHC, WB
Recommend Dilution WB: 0.25-0.5µg/mL. IHC starting at 5µg/mL. IF start at 20µg/mL.
Reactivity Human
Host Mouse
Clonality Monoclonal
Immunogen PD-1 antibody was raised against the extracellular domain of human PD-1.
Formulation PD-1 Antibody is supplied in PBS containing 0.02% sodium azide.
Concentration 1 mg/ml
Purification PD-1 Antibody is supplied as protein A purified IgG1.
Conjugation Unconjugated
Storage Condition Store at -20°C as received.
Predicted Protein Size Predicted: 32 kDa; Observed: 38 kDa
Gene Name programmed cell death 1
Background Cell-mediated immune responses are initiated by T lymphocytes that are themselves stimulated by cognate peptides bound to MHC molecules on antigen-presenting cells (APC). T-cell activation is generally self-limited as activated T cells express receptors such as PD-1 (also known as PDCD-1) that mediate inhibitory signals from the APC. PD-1 can bind two different but related ligands, PDL-1 and PDL-2. Upon binding to either of these ligands, signals generated by PD-1 inhibit the activation of the immune response in the absence of "danger signals" such as LPS or other molecules associated with bacteria or other pathogens. Evidence for this is seen in PD-1-null mice who exhibit hyperactivated immune systems and autoimmune diseases. PD-1 is thus one of a growing number of immune checkpoint proteins.
Synonyms CD279; hPD-1; hPD-l; PD1; SLEB2
Note PD-1 antibody can be used for detection of PD-1 by Western blot at 0.25 - 0.5 µg/mL. Antibody can also be used for immunohistochemistry starting at 5 µg/mL. For immunofluorescence start at 20 µg/mL.
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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