SLAMF7 Rabbit Monoclonal Antibody [Clone ID: DM11]

CAT#: TA355171

CS1 rabbit monoclonal antibody, clone DM11



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CNY 6,178.00


货期*
2周

规格
    • 100 ug

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Specifications

Product Data
Clone Name DM11
Applications ELISA, FC, IF, IP
Recommend Dilution Flow Cyt  1/100
Reactivity Human
Host Rabbit
Clonality Monoclonal
Immunogen Recombinant human CS1 (Ser23-Met226) (TP723925) produced by using human HEK293 cells
Formulation Lyophilized from sterile PBS, pH 7.4. Normally 5 % - 8 % trehalose is added as protectants before lyophilization.
Preservative: 0.1% Procline 300
Reconstitution Method Reconstitute with deionized water
Purification Purified from cell culture supernatant by affinity chromatography
Conjugation Unconjugated
Storage Condition Store at -20°C for 12 months (Avoid repeated freezing and thawing)
Predicted Protein Size 37kDa
Gene Name SLAM family member 7
Background Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. Isoform 1 mediates NK cell activation through a SH2D1A-independent extracellular signal-regulated ERK-mediated pathway (PubMed:11698418). Positively regulates NK cell functions by a mechanism dependent on phosphorylated SH2D1B. Downstream signaling implicates PLCG1, PLCG2 and PI3K (PubMed:16339536). In addition to heterotypic NK cells-target cells interactions also homotypic interactions between NK cells may contribute to activation. However, in the absence of SH2D1B, inhibits NK cell function. Acts also inhibitory in T-cells (By similarity). May play a role in lymphocyte adhesion (PubMed:11802771). In LPS-activated monocytes negatively regulates production of proinflammatory cytokines (PubMed:23695528).
Synonyms 19A; CD319; CRACC; CS1
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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