ALK Mouse Monoclonal Antibody [Clone ID: 5A4]

Specifications

Product Data
Clone Name	5A4
Applications	IHC
Recommend Dilution	1:200
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic recombinant protein corresponding to a region which spans the tyrosine kinase catalytic domain and part of the C-terminus of the NPM-ALK transcript (419-520αα)
Specificity	Human ALK protein and C-terminal ALK fusion proteins containing the immunized target sequence.
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	anaplastic lymphoma receptor tyrosine kinase
Database Link	Entrez Gene 238 Human UniProt ID Q9UM73
Background	Anaplastic large cell lymphoma (ALCL) is usually composed of large pleomorphic cells which are reported to express CD30 antigen and epithelial membrane antigen (EMA). These tumor cells tend to occur in younger individuals and may be associated with cutaneous and extranodal involvement. A proportion of these cases contain a chromosomal translocation t(2;5) (p23;q35). This results in a hybrid gene encoding part of the nucleophosmin (NPM) gene joined to the cytoplasmic domain of the anaplastic lymphoma kinase (ALK) gene, giving rise to the protein, p80. Large cell lymphomas account for approximately 25% of all non-Hodgkin's lymphomas in children and young adults, of which one third carry the NPM-ALK gene translocation.
Synonyms	CD246; NBLST3; TFG/ALK
Reference Data

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