CD68 Mouse Monoclonal Antibody [Clone ID: 514H12]

Specifications

Product Data
Clone Name	514H12
Applications	IHC
Recommend Dilution	1:100
Reactivity	Human
Host	Mouse
Clonality	Monoclonal
Immunogen	Prokaryotic fusion protein corresponding to the carboxy-terminal half of the external domain of the human CD68 molecule
Specificity	Human CD68 antigen
Formulation	Liquid tissue culture supernatant containing sodium azide as a preservative
Conjugation	Unconjugated
Storage Condition	Store at 2-8°C
Gene Name	CD68 molecule
Database Link	Entrez Gene 968 Human UniProt ID P34810
Background	The CD68 molecule is a 110 kD intracellular glycoprotein primarily reported to be associated with cytoplasmic granules and to a lesser extent the membranes of macrophages. Markers to CD68 antigen are the most frequently used for the identification of macrophages in immunohistochemistry; however, CD68 is also found in monocytes, neutrophils, basophils and large lymphocytes. The function of the CD68 molecule is not certain but these lysosomal membrane proteins are major components and may protect the membranes from attack by acid hydrolases. It is unclear if the surface-associated CD68 protein is functionally significant or due to leakage from the lysosomes. CD68 protein expression has been demonstrated in stimulated T cells and NK cells and non-hematopoietic tissues such as liver and renal tubules.
Synonyms	DKFZp686M18236; GP110; macrosialin; SCARD1
Reference Data

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