Chk2 (CHEK2) Rabbit Polyclonal Antibody

CAT#: TA374729

Phospho-Chk2-S516 Rabbit polyclonal Antibody



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CNY 2,900.00


货期*
2周

规格
    • 100 ul

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beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
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Specifications

Product Data
Applications WB
Recommend Dilution WB,1:500 - 1:2000
Reactivity Human, Mouse, Rat
Modifications Phospho S516
Host Rabbit
Clonality Polyclonal
Immunogen A synthetic phosphorylated peptide around S516 of human Chk2 (NP_009125.1).
Formulation Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Concentration lot specific
Purification Affinity purification
Conjugation Unconjugated
Storage Condition Store at -20℃. Avoid freeze / thaw cycles.
Predicted Protein Size 15-38kDa/50-65kDa
Gene Name checkpoint kinase 2
Background In response to DNA damage and replication blocks, cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated, the encoded protein is known to inhibit CDC25C phosphatase, preventing entry into mitosis, and has been shown to stabilize the tumor suppressor protein p53, leading to cell cycle arrest in G1. In addition, this protein interacts with and phosphorylates BRCA1, allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome, a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also, mutations in this gene are thought to confer a predisposition to sarcomas, breast cancer, and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
Synonyms bA444G7; CDS1; CHK2; HuCds1; LFS2; OTTHUMP00000199044; OTTHUMP00000199045; OTTHUMP00000199116; PP1425; RAD53
Reference Data
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.
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