Integrin alpha 5 (ITGA5) Human Monoclonal Antibody [Clone ID: M200 (Volociximab)]

Specifications

Product Data
Clone Name	M200 (Volociximab)
Applications	Bl, ELISA, FC, IF, IHC
Reactivity	Human
Host	Human
Clonality	Monoclonal
Immunogen	Heterodimeric α5β1Fc fusion protein
Specificity	The antibody binds to human α5β1 integrin with a Kd of 0.367 nM (determined by Biacore), an EC50 of 0.2 nM and an IC50 of 2.3 nM. The antibody binds specifically to α5β1 integrin, which is part of the superfamily of glycoprotein transmembrane receptors for ligands such as fibronectin, vitronectin, laminins and collagens. The α5β1 integrin receptor plays a key role in cellular processes such as inflammation, cell proliferation, angiogenesis and tumour metastasis. Comprising the variable domain of the original mouse antibody, a chimeric mouse:human IgG4 version of this antibody has been tested in vivo: In cynomolgus monkeys with laser-induced choroidal neovascularization (CNV), in rabbit models and in human volunteers. The antibody reached Phase II clinical trials with PDL Biopharma and Biogen-Idec.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	integrin subunit alpha 5
Database Link	Entrez Gene 3678 Human UniProt ID P08648
Synonyms	CD49e; FNRA; VLA-5; VLA5A
Note	NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar.
Reference Data

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