CD4 Rabbit Monoclonal Antibody [Clone ID: CE9.1 (Clenoliximab)]

Specifications

Product Data
Clone Name	CE9.1 (Clenoliximab)
Applications	Bl, ELISA, FC, IHC
Reactivity	Human, Chimpanzee
Host	Rabbit
Clonality	Monoclonal
Immunogen	Domain 1 of human CD4.
Specificity	The antibody binds to human CD4 with a Kd of 1.0 nM and an ED50 of 0.2 ug/ml. The antibody binds specifically to CD4, a molecule which is part of the immunolgobulin super-family, expressed on the surface of helper T cells. The CD4 molecule acts as a co-receptor in the activation of T cells, aiding the interaction between the TCR and MHC II of the antigen-presenting cell. The antibody is classified as "primatized", as the variable regions of the light and heavy chains are obtained from primates, while the lamda light chain and γ4 heavy chain constant domains are human. The antibody was engineered from the primatized IgG1 monoclonal antibody Keliximab by substituting two key residues. The role of the antibody as an immunosuppressor has been tested in vivo, by intravenous administration in chimpanzees and human volunteers. The antibody reached Phase II clinical trials with Biogen-Idec.
Formulation	PBS with 0.02% Proclin 300.
Concentration	lot specific
Conjugation	Unconjugated
Storage Condition	Please store at 4°C for up to 3 months. For longer storage, aliquot and store at -20°C. Avoid freeze and thaw cycles.
Gene Name	CD4 molecule
Database Link	Entrez Gene 920 Human UniProt ID P01730
Synonyms	CD4mut
Note	NOT FOR THERAPEUTIC USE - This is a research-grade biosimilar. This chimeric rabbit antibody was made using the variable domain sequences of the original Human IgG4 (primatized) format, for improved compatibility with existing reagents, assays and techniques.
Reference Data

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