Arg1 Chicken Polyclonal Antibody

Specifications

Product Data
Applications	IHC, WB
Recommend Dilution	WB: 1:1000
Reactivity	Guinea Pig, Human, Mouse, Rat
Host	Chicken
Clonality	Polyclonal
Immunogen	Full-length recombinant rat liver arginase I expressed in and purified from E. Coli.
Specificity	Specific for endogenous levels of the ~35-38 kDa arginase I protein.
Formulation	10 mM HEPES (pH 7.5), 150 mM NaCl, 100 µg per ml BSA and 50% glycerol.
Concentration	lot specific
Purification	Total IgY fraction
Conjugation	Unconjugated
Storage Condition	Storage at -20°C is recommended, as aliquots may be taken without freeze/thawing due to presence of 50% glycerol. Stable for at least 1 year at -20°C.
Predicted Protein Size	35/38
Gene Name	arginase 1
Database Link	Entrez Gene 29221 Rat UniProt ID P05089
Background	Arginase I, a cytosolic enzyme, is highly expressed in the liver and is a component of the urea cycle (Jenkinson et al, 1996). There are two isoforms of arginase, both catalyze the conversion of arginine to ornithine and urea, but differ based on subcellular localization, tissue distribution, and enzymatic properties (Jenkinson et al, 1996). Arginase I has been identified in macrophages in response to various pathogen exposures causing an upregulation of inducible nitric oxide synthase, iNOS, yielding increased levels of nitric oxide (Morris et al, 1998) and inflammation (Poljakovic et al, 2007).
Synonyms	ARG1
Note	Total IgY fraction.
Reference Data

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