LIM Kinase 1 (LIMK1) Mouse Monoclonal Antibody (HRP conjugated) [Clone ID: OTI8C8]

CAT#: TA502978BM

LIMK1 (LIM Kinase 1 ) mouse monoclonal antibody, clone OTI8C8 (formerly 8C8), HRP conjugated

Conjugation: Unconjugated Biotin HRP



  View other "OTI8C8" antibodies (4)

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CNY 3,990.00


货期*
2周

规格
    • 100 ul

经常一起买 (3)
beta Actin Mouse Monoclonal Antibody, Clone OTI1, Loading Control
    • 30 ul

CNY 300.00
CNY 1,430.00


Recombinant protein of human LIM domain kinase 1 (LIMK1), 20 µg
    • 20 ug

CNY 2,900.00
CNY 6,650.00


Transient overexpression lysate of LIM domain kinase 1 (LIMK1)
    • 100 ug

CNY 4,840.00

Specifications

Product Data
Clone Name OTI8C8
Applications FC, IF, IHC, WB
Recommend Dilution WB 1:1000, IHC 1:150, IF 1:100, FLOW 1:100
Reactivity Human, Mouse, Rat
Host Mouse
Clonality Monoclonal
Immunogen Full length human recombinant protein of human LIMK1(NP_002305) produced in HEK293T cell.
Formulation PBS (pH 7.3) containing 1% BSA, 50% glycerol.
Concentration 0.5 mg/ml
Purification Purified from mouse ascites fluids or tissue culture supernatant by affinity chromatography (protein A/G)
Conjugation HRP
Storage Condition Store at -20°C as received.
Predicted Protein Size 72.4 kDa
Gene Name LIM domain kinase 1
Background There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.
Synonyms LIMK; LIMK-1
Reference Data
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Axon guidance, Fc gamma R-mediated phagocytosis, Regulation of actin cytoskeleton
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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