VR1 (TRPV1) Rabbit Polyclonal Antibody (Biotin conjugated)

Specifications

Product Data
Applications	WB
Recommend Dilution	WB: 1:500
Reactivity	Human, Mouse, Rat
Host	Rabbit
Clonality	Polyclonal
Immunogen	Recombinant protein of human TRPV1
Formulation	PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Concentration	0.5 mg/ml
Purification	Purified from the immunized serum by affinity chromatography (Protein A/G)
Conjugation	Biotin
Storage Condition	Store at -20°C as received.
Predicted Protein Size	94.8 kDa
Gene Name	transient receptor potential cation channel subfamily V member 1
Database Link	NP_542435 Entrez Gene 83810 RatEntrez Gene 193034 MouseEntrez Gene 7442 Human UniProt ID Q8NER1
Background	Capsaicin, the main pungent ingredient in hot chili peppers, elicits a sensation of burning pain by selectively activating sensory neurons that convey information about noxious stimuli to the central nervous system. The protein encoded by this gene is a receptor for capsaicin and is a non-selective cation channel that is structurally related to members of the TRP family of ion channels. This receptor is also activated by increases in temperature in the noxious range, suggesting that it functions as a transducer of painful thermal stimuli in vivo. Four transcript variants encoding the same protein, but with different 5' UTR sequence, have been described for this gene. [provided by RefSeq, Jul 2008]
Synonyms	VR1
Reference Data
Protein Families	Druggable Genome, Ion Channels: Transient receptor potential, Transmembrane
Protein Pathways	Neuroactive ligand-receptor interaction

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