Human Myeloperoxidase (MPO) ELISA Kit 1 x 96

Specifications

Product Data
Description	Human Myeloperoxidase (MPO) ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	3.5 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Curve Range	0.312ng/ml-20ng/ml
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of Human MPO
Sensitivity	110pg/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	MPO Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human MPO Standard (1µg/ml)|0.1 mL 100x Biotin conjugated MPO Detection Antibody|0.12 mL 100x SA-HRP Conjugate0.12 mLAssay Buffer|30 mL Standard Diluent10 mL Sample Diluent25 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer|3 pieces
Background	Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene. MPO protein is a 150-kDa cationic heterotetramer consisting of two 15-kDa light chains and two variable-weight glycosylated heavy chains bound to a prosthetic heme group, arranged as a homodimer of heterodimers. MPO is most abundantly expressed in neutrophil granulocytes, and produces hypohalous acids to carry out their antimicrobial activity, including hypochlorous acid. It is a lysosomal protein stored in azurophilic granules of the neutrophil and released into the extracellular space during degranulation. Myeloperoxidase deficiency is a hereditary deficiency of the enzyme, which predisposes to immune deficiency. Recent studies have reported an association between elevated myeloperoxidase levels and the severity of coronary artery disease, and elevated MPO levels increased the risk for cardiovascular mortality. It has also been suggested that myeloperoxidase plays a significant role in the development of the atherosclerotic lesion and rendering plaques unstable. MPO could serve as a sensitive predictor for myocardial infarction.
Gene Symbol	MPO
Standard Curve	Data image of Human Myeloperoxidase (MPO) ELISA Kit.

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