Human PSMA (FOLH1) ELISA Kit 1 x 96

Specifications

Product Data
Description	Human PSMA (FOLH1) ELISA Kit 1 x 96
Size	1 x 96 wells
Format	8x12 divisible strips
Assay Type	Sandwich
Assay Length	3.5 hours incubations; 0.5 hour washing and analyzing samples
Signal	Colorimetric
Sample Type	Human serum, plasma and other biological fluids.
Sample Volume	100µl
Specificity	This kit is used for quantitative detection of PSMA
Sensitivity	0.26ng/ml
Reactivity	Human
Cross Reactivity	There is no detectable cross-reactivity with other relevant proteins.
Interference	No significant interference observed with available related molecules.
Components	PSMA Monoclonal Antibody Coated 96-well Plate in foil pouch with desiccant|1 plate Recombinant Human PSMA Standard (2.5µg/ml)|0.1 mL 100x Biotin conjugated PSMA Detection Antibody|0.12 mL 100x SA-HRP Conjugate0.12 mLAssay Buffer|40 mL Sample Diluent|30 mL Wash Buffer Concentrate 20X|60 mL TMB Substrate|12 mL Stop Solution|12 mL Plate Sealer|3 pieces
Background	Prostate-specific membrane antigen (PSMA) is also known as folate hydrolase 1 (FOLH1), an enzyme that in humans is encoded by the FOLH1 gene. Human PSMA contains 750 amino acids and its MW is about 84 kDa. It is a zinc metalloenzyme and belongs to class II membrane glycoprotein. It is mainly expressed in prostate epithelium, the proximal tubules of the kidney, the jejunal brush border of the small intestine and Ganglia of the nervous system. PSMA catalyzes the hydrolysis of N-acetylaspartylglutamate (NAAG) to glutamate and N-acetylaspartate (NAA). PSMA is also responsible for removal of gamma-linked glutamates from polygammaglutamate folate in the small intestine. In inflammatory bowel diseases, PSMA activity is elevated. PSMA is down-regulated in benign prostate hyperplasia and overexpressed in primary and metastatic prostate cancer. In some prostate cancers. In human prostate cancer, the higher expressing tumors are associated with quicker time to progression and a greater percentage of patients suffering relapse. One study suggests that serum PSMA may be a more effective biomarker than prostate specific antigen for differentiating benign from malignant prostate disease.
Gene Symbol	FOLH1
Standard Curve	Data image of Human PSMA (FOLH1) ELISA Kit.

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