Caspase 8 (CASP8) (NM_033358) Human 3' UTR Clone

Specifications

Product Data
Product Name	Caspase 8 (CASP8) (NM_033358) Human 3' UTR Clone
Vector	pMirTarget
Synonyms	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
ACCN	NM_033358
Insert Size	144 bp
Sequence Data	Insert Sequence (showhide) >SC200811 3’UTR clone of NM_033358 The sequence shown below is from the reference sequence of NM_033358. The complete sequence of this clone may contain minor differences, such as SNPs. Blue=Stop Codon Red=Cloning site GGCAAGTTGGACGCCCGCAAGATCCGCGAGATTCTCATTAAGGCCAAGAAGGGCGGAAAGATCGCCGTG TAACAATTGGCAGAGCTCAGAATTCAAGCGATCGCC GGAGAAAGTGCCCAAACTTCACAGCATTAGGGACAGGAATGGAACACACTTGGATGCAGGGTTTGAGAA TGTTTTTAGCTGGTGGCAATAAATATTAGAAGCCTGCAGAATCCAGCTACGAATATAGAGGGTTTTGCT CTTGAA ACGCGTAAGCGGCCGCGGCATCTAGATTCGAAGAAAATGACCGACCAAGCGACGCCCAACCTGCCATCA CGAGATTTCGATTCCACCGCCGCCTTCTATGAAAGG
Restriction Sites	SgfI-MluI
OTI Disclaimer	Our molecular clone sequence data has been matched to the sequence identifier above as a point of reference. Note that the complete sequence of this clone is largely the same as the reference sequence but may contain minor differences , e.g., single nucleotide polymorphisms (SNPs).
Reference Data
RefSeq	NM_033358.4
Synonyms	ALPS2B; CAP4; Casp-8; FLICE; MACH; MCH5
Summary	This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls, which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described, although not all variants have had their full-length sequences determined. [provided by RefSeq, Jul 2008]
Locus ID	841
MW	5.3

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