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Gastric Inhibitory Polypeptide Receptor (GIPR) (NM_000164) Human Untagged Clone
CAT＃: SC110906
GIPR (untagged)-Human gastric inhibitory polypeptide receptor (GIPR)
CNY 3,656.00
CNY 7,220.00
| Cited in 6 publications. |
Product images
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | PGQTL2 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene sequence for NM_000164, RT-PCR generated
ATGACTACCTCTCCGATCCTGCAGCTGCTGCTGCGGCTCTCACTGTGCGGGCTGCTGCTC CAGAGGGCGGAGACAGGCTCTAAGGGGCAGACGGCGGGGGAGCTGTACCAGCGCTGGGAA CGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCCGCGGAACCGCCTTCAGGCCTCGCC TGTAACGGGTCCTTCGATATGTACGTCTGCTGGGACTATGCTGCACCCAATGCCACTGCC CGTGCGTCCTGCCCCTGGTACCTGCCCTGGCACCACCATGTGGCTGCAGGTTTCGTCCTC CGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGGAGAGACCATACACAATGTGAGAAC CCAGAGAAGAATGAGGCCTTTCTGGACCAAAGGCTCATCTTGGAGCGGTTGCAGGTCATG TACACTGTCGGCTACTCCCTGTCTCTCGCCACACTGCTGCTAGCCCTGCTCATCTTGAGT TTGTTCAGGCGGCTACATTGCACTAGAAACTATATCCACATCAACCTGTTCACGTCTTTC ATGCTGCGAGCTGCGGCCATTCTCAGCCGAGACCGTCTGCTACCTCGACCTGGCCCCTAC CTTGGGGACCAGGCCCTTGCGCTGTGGAACCAGGCCCTCGCTGCCTGCCGCACGGCCCAG ATCGTGACCCAGTACTGCGTGGGTGCCAACTACACGTGGCTGCTGGTGGAGGGCGTCTAC CTGCACAGTCTCCTGGTGCTCGTGGGAGGCTCCGACGAGGGCCACTTCCGCTACTACCTG CTCCTCGGCTGGGGGGCCCCCGCGCTTTTCGTCATTCCCTGGGTGATCGTCAGGTACCTG TACGAGAACACGCAGTGCTGGGAGCGCAACGAAGTCAAGGCCATTTGGTGGATTATACGG ACCCCCATCCTCATGACCATCTTGATTAATTTCCTCATTTTTATCCGCATTCTTGGCATT CTCCTGTCCAAGCTGAGGACACGGCAAATGCGCTGCCGGGATTACCGGCTGAGGCTGGCT CGCTCCACGCTGACGCTGGTGCCCCTGCTGGGTGTCCACGAGGTGGTGTTTGCTCCCGTG ACAGAGGAACAGGCCCGGGGCGCCCTGCGCTTCGCCAAGCTCGGCTTTGAGATCTTCCTC AGCTCCTTCCAGGGCTTCCTGGTCAGCGTCCTCTACTGCTTCATCAACAAGGAGGTGCAG TCGGAGATCCGCCGTGGCTGGCACCACTGCCGCCTGCGCCGCAGCCTGGGCGAGGAGCAA CGCCAGCTCCTGGAGCGCGCCTTCCGGGCCCTGCCCTCCGGCTCCGGCCCGGGCGAGGTC CCCACCAGCCGCGGCTTGTCCTCGGGGACCCTCCCAGGGCCTGGGAATGAGGCCAGCCGG GAGTTGGAAAGTTACTGCTAG >OriGene 5' read for NM_000164 unedited
NGTAACGTTCGAAATTTGTATACGACTCACTATAGGCGGCCGCCAGTGTGATGGATATCT GCAGAATTCGGCTTGATCCTCACGATGACTACCTCTCCGATCCTGCAGCTGCTGCTGCGG CTCTCACTGTGCGGGCTGCTGCTCCAGAGGGCGGAGACAGGCTCTAAGGGGCAGACGGCG GGGGAGCTGTACCAGCGCTGGGAACGGTACCGCAGGGAGTGCCAGGAGACCTTGGCAGCC GCGGAACCGCCTTCAGGCCTCGCCTGTAACGGGTCCTTCGATATGTACGTCTGCTGGGAC TATGCTGCACCCAATGCCACTGCCCGTGCGTCCTGCCCCTGGTACCTGCCCTGGCACCAC CATGTGGCTGCAGGTTTCGTCCTCCGCCAGTGTGGCAGTGATGGCCAATGGGGACTTTGG AGAGACCATACACAATGTGAGAACCCAGAGAAGAATGAGGCCTTTCTGGACCAAAGGCTC ATCTTGGAGCGGTTGCAGGTCATGTACACTGTCGGCTACTCCCTGTCTCTCGCCACACTG CTGCTAGCCCTGCTCATCTTGAGTTTGTTCAGGCGGCTACATTGCACTAGAAACTATATC CACATCAACCTGTTCACGTCTTTCATGCTGCGAGCTGCGGCCATTCTCAGCCGAGACCGT CTGCTACCTCGACCTGGCCCCTACCTTGGGGACCAGGCCCTTGCGCTGTGGAACCAGGCC CTCGCTGCCTGGCGCACGGCCCAGATCGTGACCCAGTACTGCGTGGGTGCCAACTACACG TGGCTGCTGGTGGAGGGCGTCTACCTGCACAGTCTTCTGGTGCTCGTGGGGAGCTCCGAC GAGGGCCACTTTCGCTACTACCTGCTNCTCGGCTGGGGGGCCCCCGCGCTTTTCGTCATT CCTGGGA >OriGene 3' read for NM_000164 unedited
CGTTCGGCACATTGGCGATGGCCAACTTCCAGGCCAGGGAAGAGCATGGGGAAGGGGTCA CAGGGCATGCCACCCGGGTATCTGTTCAGGCAAACAGCTATGCACCGCGGCCCGCAATCT AGAGTCGACAAGCTTGATATCGGTACCGAGCTCGGATCCACTAGTAACGGCCGCCAGTGT GCTGGAATTCGGCTTCCCTAGCAGTAACTTTCCAACTCCCGGCTGGCCTCATTCCCAGGC CCTGGGAGGGTCCCCGAGGACAAGCCGCGGCTGGTGGGGACCTCGCCCGGGCCGGAGCCG GAGGGCAGGGCCCGGAAGGCGCGCTCCAGGAGCTGGCGTTGCTCCTCGCCCAGGCTGCGG CGCAGGCGGCAGTGGTGCCAGCCACGGCGGATCTCCGACTGCACCTCCTTGTTGATGAAG CAGTAGAGGACGCTGACCAGGAAGCCCTGGAAGGAGCTGAGGAAGATCTCAAAGCCGAGC TTGGCGAAGCGCAGGGCGCCCCGGGCCTGTTCCTCTGTCACGGGAGCAAACACCACCTCG TGGACACCCAGCAGGGGCACCAGCGTCAGCGTGGAGCGAGCCAGCCTCAGCCGGTAATCC CGGCAGCGCATTTGCCGTGTCCTCAGCTTGGACAGGAGAATGCCAAGAATGCGGATAAAA ATGAGGAAATTAATCAAGATGGTCATGAGGATGGGNGGTCCGTATAATCCACCAAATGGC CTTGACTTCGTTGCGCTCCCAGCACTGCGTGTTCTCGTACAGGTACCTGACGATCACCCA GGGAATGACGAANAGCGCGGGGGCCCCCCCAGCCGAGAGCATGTAGTAGCGGNAAGTGGG CCCTCGTCGGAGCCTCCCACGAGCACCAGNAGACTGTGCATGTAGACGCCCTCCACCACA CCAGTTGTAGTCGC |
| Restriction Sites | Please inquire |
| ACCN | NM_000164 |
| Insert Size | 1700 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000164.2, NP_000155.1 |
| RefSeq Size | 2024 bp |
| RefSeq ORF | 1401 bp |
| Locus ID | 2696 |
| UniProt ID | P48546 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Neuroactive ligand-receptor interaction |
| Gene Summary | This gene encodes a G-protein coupled receptor for gastric inhibitory polypeptide (GIP), which was originally identified as an activity in gut extracts that inhibited gastric acid secretion and gastrin release, but subsequently was demonstrated to stimulate insulin release in the presence of elevated glucose. Mice lacking this gene exhibit higher blood glucose levels with impaired initial insulin response after oral glucose load. Defect in this gene thus may contribute to the pathogenesis of diabetes. [provided by RefSeq, Oct 2011] Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (6)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Glucose‐dependent insulinotropic polypeptide receptor antagonist treatment causes a reduction in weight gain in ovariectomised high fat diet‐fed mice
,null,
British Journal of Pharmacology
,PubMed ID 35710141
[GIPR]
|
|
N‐terminal alterations turn the gut hormone GLP‐2 into an antagonist with gradual loss of GLP‐2 receptor selectivity towards more GLP‐1 receptor interaction
,null,
British Journal of Pharmacology
,PubMed ID 35523760
[GIPR]
|
|
Spatiotemporal GLP-1 and GIP receptor signaling and trafficking/recycling dynamics induced by selected receptor mono- and dual-agonists
,Novikoff, A;O'Brien, SL;Bernecker, M;Grandl, G;Kleinert, M;Knerr, PJ;Stemmer, K;Klingenspor, M;Zeigerer, A;DiMarchi, R;Tschöp, MH;Finan, B;Calebiro, D;Müller, TD;,
Molecular metabolism
,PubMed ID 33556643
[GIPR]
|
|
Human GIP(3-30)NH2inhibits G protein-dependent as well as G protein-independent signaling and is selective for the GIP receptor with high-affinity binding to primate but not rodent GIP receptors
,Gabe, MBN;Sparre-Ulrich, AH;Pedersen, MF;Gasbjerg, LS;Inoue, A;Bräuner-Osborne, H;Hartmann, B;Rosenkilde, MM;,
Biochem. Pharmacol.
,PubMed ID 29378179
[GIPR]
|
|
GIP (3-30) NH 2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostation release
,Sparre-Ulrich, A;Gabe, M;Gasbjerg, L;Christiansen, C;Svendsen, B;Hartmann, B;Holst, J;Rosenkilde, M;,
Biochemical Pharmacology
,PubMed ID 28237651
[GIPR]
|
|
Species-specific action of (Pro3)GIP - an efficacious agonist on human GIP receptor, but partial agonist and competitive antagonist on rat and mouse GIP receptors
,Sparre-Ulrich, AH;Hansen, LS;Svendsen, B;Christensen, M;Knop, FK;Hartmann, B;Holst, JJ;Rosenkilde, MM;,
Br. J. Pharmacol.
,PubMed ID 26359804
[GIPR]
|
Documents
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Resources
Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC210811 | GIPR (Myc-DDK-tagged)-Human gastric inhibitory polypeptide receptor (GIPR) |
CNY 3,656.00 |
|
| RC210811L1 | Lenti ORF clone of Human gastric inhibitory polypeptide receptor (GIPR), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC210811L2 | Lenti ORF clone of Human gastric inhibitory polypeptide receptor (GIPR), mGFP tagged |
CNY 6,056.00 |
|
| RC210811L3 | Lenti ORF clone of Human gastric inhibitory polypeptide receptor (GIPR), Myc-DDK-tagged |
CNY 5,890.00 |
|
| RC210811L4 | Lenti ORF clone of Human gastric inhibitory polypeptide receptor (GIPR), mGFP tagged |
CNY 5,890.00 |
|
| RG210811 | GIPR (tGFP-tagged) - Human gastric inhibitory polypeptide receptor (GIPR) |
CNY 4,370.00 |
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