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Cytochrome P450 2B6 (CYP2B6) (NM_000767) Human Untagged Clone
CAT＃: SC125490
CYP2B6 (untagged)-Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6)
CNY 2,950.00
| Cited in 1 publication. |
Product images
CNY 1,999.00
CNY 2,700.00
Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CPB6; CYP2B; CYP2B7; CYP2B7P; CYPIIB6; EFVM; IIB1; P450 |
| Vector | pCMV6-XL4 |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | None |
| Sequence Data |
>OriGene ORF sequence for NM_000767 edited
GGCGGCCGCGAATTCGGCACCAGGCAGGGCAGTCAGACCAGGACCATGGAACTCAGCGTC CTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCCTGGTTCAGTGCCACCCTAAC ACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCCTTTTGGGAAACCTTCTGCAG ATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCCGAGAGAAATATGGGGACGTC TTCACGGTACACCTGGGACCCAGGCCCGTGGTCATGCTGTGTGGAGTAGAGGCCATACGG GAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGGGAAAAATCGCCATGGTCGAC CCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAAACCGCTGGAAGGTGCTTCGG CGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAAAGCGGAGTGTGGAGGAGCGG ATTCAGGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGAAATCCAAGGGGGCCCTCATG GACCCCACCTTCCTCTTCCAGTCCATTACCGCCAACATCATCTGCTCCATCGTCTTTGGA AAACGATTCCACTACCAAGATCAAGAGTTCCTGAAGATGCTGAACTTGTTCTACCAGACT TTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCTCTTCTCTGGCTTCTTGAAA TACTTTCCTGGGGCACACAGGCAAGTTTACAAAAACCTGCAGGAAATCAATGCTTACATT GGCCACAGTGTGGAGAAGCACCGTGAAACCCTGGACCCCAGCGCCCCCAAGGACCTCATC GACACCTACCTGCTCCACATGGAAAAAGAGAAATCCAACGCACACAGTGAATTCAGCCAC CAGAACCTCAACCTCAACACGCTCTCGCTCTTCTTTGCTGGCACTGAGACCACCAGCACC ACTCTCCGCTACGGCTTCCTGCTCATGCTCAAATACCCTCATGTTGCAGAGAGAGTCTAC AGGGAGATTGAACAGGTGATTGGCCCACATCGCCCTCCAGAGCTTCATGACCGAGCCAAA ATGCCATACACAGAGGCAGTCATCTATGAGATTCAGAGATTTTCCGACCTTCTCCCCATG GGTGTGCCCCACATTGTCACCCAACACACCAGCTTCCGAGGGTACATCATCCCCAAGGAC ACAGAAGTATTTCTCATCCTGAGCACTGCTCTCCATGACCCACACTACTTTGAAAAACCA GACGCCTTCAATCCTGACCACTTTCTGGATGCCAATGGGGCACTGAAAAAGACTGAAGCT TTTATCCCCTTCTCCTTAGGGAAGCGGATTTGTCTTGGTGAAGGCATCGCCCGTGCGGAA TTGTTCCTCTTCTTCACCACCATCCTCCAGAACTTCTCCATGGCCAGCCCCGTGGCCCCA GAAGACATCGATCTGACACCCCAGGAGTGTGGTGTGGGCAAAATACCCCCAACATACCAG ATCCGCTTCCTGCCCCGCTGAAGGGGCTGAGGGAAGGGGGTCAAAGGATTCCAGGGTCAT TCAGTGTCCCCGCCTCTGTAGACAATGGCTCTGACTCCCCGCAACTTCCTGCCTCTGAGA GACCTGCTACAAGCCAGCTTCCTTCCCCTCCATGGCACCAGTTGTCTGAGGTCACATTGC AAGTGAGTGCAGGAGTGAGATT >OriGene 5' read for NM_000767 unedited
TGTAATACGACTCACTATAGGGCGGCCGCGAATTCGGCACCAGGCAGGGCAGTCAGACCA GGACCATGGAACTCAGCGTCCTCCTCTTCCTTGCACTCCTCACAGGACTCTTGCTACTCC TGGTTCAGTGCCACCCTAACACCCATGACCGCCTCCCACCAGGGCCCCGCCCTCTGCCCC TTTTGGGAAACCTTCTGCAGATGGATAGAAGAGGCCTACTCAAATCCTTTCTGAGGTTCC GAGAGAAATATGGGGACGTCTTCACGGTACACCTGGGACCCAGGCCCGTGGTCATGCTGT GTGGAGTAGAGGCCATACGGGAGGCCCTTGTGGACAAGGCTGAGGCCTTCTCTGGCCGGG GAAAAATCGCCATGGTCGACCCATTCTTCCGGGGATATGGTGTGATCTTTGCCAATGGAA ACCGCTGGAAGGTGCTTCGGCGATTCTCTGTGACCACTATGAGGGACTTCGGGATGGGAA AGCGGAGTGTGGAGGAGCGGATTCANGAGGAGGCTCAGTGTCTGATAGAGGAGCTTCGGA AATCCAAGGGGGCCCTCATGGACCCCACCTTCCTCTTCCAGTCCATTACCCGCCACATCA TCTGCNTCATCGTCTTTGGAAAACGATCCACTACCCAGATCAAGAAGTCCCTGAGATGCT GAAACTTGTCTACCCAGACTTTTCACTCATCAGCTCTGTATTCGGCCAGCTGTTTGAGCT CTTCTCTGGCTTCTGAAATACTTTCCTGGNGGCACACAGCAGTTTACAAAAACCTGGCAG AAAATCATGCTTACATTGGCCCAGTGTGGAGAACCACCGTGAAACCTGGACCCAACGCCC CAAGGACTNATNGAACCTACCTGCTCCAATGGAANNAGAGAAATCACGCCACAGTGAATT AGNCCCAGAACTCNNACTNAACGCTTTTGTTTTNTTGTTGGACTGAAACACAGNACCATC TCGNTACGGTNCTGCTAGCTAATACCTCTGTTGCAAAAGTTACAGAGATTGACAGGGATG GCCCATGGCTCAN >OriGene 3' read for NM_000767 unedited
NNAAATACTGTGTACCCGGCCCGCATGCGAGGATCGAGTTAATCTTTTTTTTTTTTTTTT TTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTTCAGGCTTTAAAAATGTTTA TTTAATTCTCAGCAAATTTGAAGGAACATTTCAGGGAAATCCAAAGCCCCCGTGCAAAAT CCCCCAGCTTAGGGAACCTGGGCCAAGGGGGCTTTTTTAATAATTGAACCCGTAGGAGGA GGCCCTTGGGAATGAGGATGGGGAAAAACTACCCCAGGGGGGGACTGGGGTTTACAACAG GCCCAAACCTAAAAAATAGCTTTCAACATGAAAGCCCCCCGCCCCAAAAAATCCCATTTT ATGCCTGTAATATCACCCCTTTGGAACCCTGGGGGGGGGGGATCACCTGGGGCCAGGAGC TCACCACCAGCCTGGCCAACATGTCCCTCCTAAAACTCCCAAAAAATTACCCGGGCCTGG GAATACATGCCTGTAATCCCAGCTACTTGGGAGCTGAAACTGGAAAATCTCTTGATCTTG GAAGGCAAAGGTTGCAGTGAACAAAAATTGCCCCATAGCACTCCAGCCTGGGAAACAAAG CAAGGTTATTTTCAAAAAAAAAAAAAAACAAATTTGGTTGATTTTGTTTTGGGAAAATTT CAAAATTGGAAAGCCCTAGGGACAAAAACCAATTTGCCGGGCCCCAATTTAAAAAAAAAA GGGGGTTGGGGAGGGGCCACCTTTAAAGGTTGGGTTTGGGGGGGGGGAAAAAAATAAAAA ATTTTGGGCCGTGGGAAATCCCCTGCCTCCGGGGTGTTAAAACCCCCTAAAAAAACAAAT TTTCCCCCCCCCTGTGGGGGGGCCCCCTGTGAAACCCCCTCTCCCCGAGGGTTGGGCGGG AAAAAATCTTCTCCCCCCCTTTTGGGGGTTTTCCGGCCACAAAGGGCCCCCCCTC |
| Restriction Sites | NotI-NotI |
| ACCN | NM_000767 |
| Insert Size | 3100 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_000767.4, NP_000758.1 |
| RefSeq Size | 3052 bp |
| RefSeq ORF | 1476 bp |
| Locus ID | 1555 |
| UniProt ID | P20813 |
| Domains | p450 |
| Protein Families | Druggable Genome, P450 |
| Protein Pathways | Arachidonic acid metabolism, Drug metabolism - cytochrome P450, Metabolic pathways, Metabolism of xenobiotics by cytochrome P450, Retinol metabolism |
| Gene Summary | This gene, CYP2B6, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize some xenobiotics, such as the anti-cancer drugs cyclophosphamide and ifosphamide. Transcript variants for this gene have been described; however, it has not been resolved whether these transcripts are in fact produced by this gene or by a closely related pseudogene, CYP2B7. Both the gene and the pseudogene are located in the middle of a CYP2A pseudogene found in a large cluster of cytochrome P450 genes from the CYP2A, CYP2B and CYP2F subfamilies on chromosome 19q. [provided by RefSeq, Jul 2008] |
Citations (1)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
|
Potential Contribution of Cytochrome P450 2B6 to Hepatic 4-Hydroxycyclophosphamide Formation In Vitro and In Vivo
,Brianne S. Raccor, Adam J. Claessens, Jean C. Dinh, Julie R. Park, Douglas S. Hawkins, Sushma S. Thomas, Karen W. Makar, Jeannine S. McCune, and Rheem A. Totah,
Drug Metab. Dispos., Jan 2012; 40: 54 - 63.
[CYP2B6]
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| RC217236 | CYP2B6 (Myc-DDK-tagged)-Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6) |
CNY 3,656.00 |
|
| RC217236L1 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC217236L2 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6), mGFP tagged |
CNY 6,180.00 |
|
| RC217236L3 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6), Myc-DDK-tagged |
CNY 6,056.00 |
|
| RC217236L4 | Lenti ORF clone of Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6), mGFP tagged |
CNY 6,056.00 |
|
| RG217236 | CYP2B6 (tGFP-tagged) - Human cytochrome P450, family 2, subfamily B, polypeptide 6 (CYP2B6) |
CNY 4,750.00 |
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