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CXCR2 (NM_001557) Human Untagged Clone
CAT＃: SC321915
CXCR2 (untagged)-Human chemokine (C-X-C motif) receptor 2 (CXCR2), transcript variant 1
CNY 2,950.00
| Cited in 2 publications. |
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热销推荐Specifications
| Product Data | |
| Type | Human Untagged Clone |
| Tag | Tag Free |
| Synonyms | CD182; CDw128b; CMKAR2; IL8R2; IL8RA; IL8RB |
| Vector | pCMV6-AC |
| E. coli Selection | Ampicillin (100 ug/mL) |
| Mammalian Cell Selection | Neomycin |
| Sequence Data |
>OriGene sequence for NM_001557.2
CTTCAGACTGGTAGGCTCCTCCAGAAGCCATCAGACAGGAAGATGTGAAAATCCCCAGCA
CTCATCCCAGAATCACTAAGTGGCACCTGTCCTGGGCCAAAGTCCCAGGACAGACCTCAT TGTTCCTCTGTGGGAATACCTCCCCAGGAGGGCATCCTGGATTTCCCCCTTGCAACCCAG GTCAGAAGTTTCATCGTCAAGGTTGTTTCATCTTTTTTTTCCTGTCTAACAGCTCTGACT ACCACCCAACCTTGAGGCACAGTGAAGACATCGGTGGCCACTCCAATAACAGCAGGTCAC AGCTGCTCTTCTGGAGGTGTCCTACAGGTGAAAAGCCCAGCGACCCAGTCAGGATTTAAG TTTACCTCAAAAATGGAAGATTTTAACATGGAGAGTGACAGCTTTGAAGATTTCTGGAAA GGTGAAGATCTTAGTAATTACAGTTACAGCTCTACCCTGCCCCCTTTTCTACTAGATGCC GCCCCATGTGAACCAGAATCCCTGGAAATCAACAAGTATTTTGTGGTCATTATCTATGCC CTGGTATTCCTGCTGAGCCTGCTGGGAAACTCCCTCGTGATGCTGGTCATCTTATACAGC AGGGTCGGCCGCTCCGTCACTGATGTCTACCTGCTGAACCTAGCCTTGGCCGACCTACTC TTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCAAGGTGAATGGCTGGATTTTTGGCACA TTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAACTTCTATAGTGGCATCCTGCTA CTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTCCATGCCACACGCACACTGACC CAGAAGCGCTACTTGGTCAAATTCATATGTCTCAGCATCTGGGGTCTGTCCTTGCTCCTG GCCCTGCCTGTCTTACTTTTCCGAAGGACCGTCTACTCATCCAATGTTAGCCCAGCCTGC TATGAGGACATGGGCAACAATACAGCAAACTGGCGGATGCTGTTACGGATCCTGCCCCAG TCCTTTGGCTTCATCGTGCCACTGCTGATCATGCTGTTCTGCTACGGATTCACCCTGCGT ACGCTGTTTAAGGCCCACATGGGGCAGAAGCACCGGGCCATGCGGGTCATCTTTGCTGTC GTCCTCATCTTCCTGCTCTGCTGGCTGCCCTACAACCTGGTCCTGCTGGCAGACACCCTC ATGAGGACCCAGGTGATCCAGGAGACCTGTGAGCGCCGCAATCACATCGACCGGGCTCTG GATGCCACCGAGATTCTGGGCATCCTTCACAGCTGCCTCAACCCCCTCATCTACGCCTTC ATTGGCCAGAAGTTTCGCCATGGACTCCTCAAGATTCTAGCTATACATGGCTTGATCAGC AAGGACTCCCTGCCCAAAGACAGCAGGCCTTCCTTTGTTGGCTCTTCTTCAGGGCACACT TCCACTACTCTCTAAGACCTCCTGCCTAAGTGCAGCCCCGTGGGGTTCCTCCCTTCTCTT CACAGTCACATTCCAAGCCTCATGTCCACTGGTTCTTCTTGGTCTCAGTGTCAATGCAGC CCCCATTGTGGTCACAGGAAGTAGAGGAGGCCACGTTCTTACTAGTTTCCCTTGCATGGT TTAGAAAGCTTGCCCTGGTGCCTCACCCCTTGCCATAATTACTATGTCATTTGCTGGAGC TCTGCCCATCCTGCCCCTGAGCCCATGGCACTCTATGTTCTAAGAAGTGAAAATCTACAC TCCAGTGAGACAGCTCTGCATACTCATTAGGATGGCTAGTATCAAAAGAAAGAAAATCAG GCTGGCCAACGGGGTGAAACCCTGTCTCTACTAAAAATACAAAAAAAAAAAAAAATTAGC CGGGCGTGGTGGTGAGTGCCTGTAATCACAGCTACTTGGGAGGCTGAGATGGGAGAATCA CTTGAACCCGGGAGGCAGAGGTTGCAGTGAGCCGAGATTGTGCCCCTGCACTCCAGCCTG AGCGACAGTGAGACTCTGTCTCAGTCCATGAAGATGTAGAGGAGAAACTGGAACTCTCGA GCGTTGCTGGGGGGGATTGTAAAATGGTGTGACCACTGCAGAAGACAGTATGGCAGCTTT CCTCAAAACTTCAGACATAGAATTAACACATGATCCTGCAATTCCACTTATAGGAATTGA CCCACAAGAAATGAAAGCAGGGACTTGAACCCATATTTGTACACCAATATTCATAGCAGC TTATTCACAAGACCCAAAAGGCAGAAGCAACCCAAATGTTCATCAATGAATGAATGAATG GCTAAGCAAAATGTGATATGTACCTAACGAAGTATCCTTCAGCCTGAAAGAGGAATGAAG TACTCATACATGTTACAACACGGACGAACCTTGAAAACTTTATGCTAAGTGAAATAAGCC AGACATCAACAGATAAATAGTTTATGATTCCACCTACATGAGGTACTGAGAGTGAACAAA TTTACAGAGACAGAAAGCAGAACAGTGATTACCAGGGACTGAGGGGAGGGGAGCATGGGA AGTGACGGTTTAATGGGCACAGGGTTTATGTTTAGGATGTTGAAAAAGTTCTGCAGATAA ACAGTAGTGATAGTTGTACCGCAATGTGACTTAATGCCACTAAATTGACACTTAAAAATG GTTTAAATGGTCAATTTTGTTATGTATATTTTATATCAATTTAAAAAAAAACCTGAGCCC CAAAAGGTATTTTAATCACCAAGGCTGATTAAACCAAGGCTAGAACCACCTGCCTATATT TTTTGTTAAATGATTTCATTCAATATCTTTTTTTTAATAAACCATTTTTACTTGGGTGTT TAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA AAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAAA |
| Restriction Sites | Please inquire |
| ACCN | NM_001557 |
| Insert Size | 2900 bp |
| OTI Disclaimer | Our molecular clone sequence data has been matched to the reference identifier above as a point of reference. Note that the complete sequence of our molecular clones may differ from the sequence published for this corresponding reference, e.g., by representing an alternative RNA splicing form or single nucleotide polymorphism (SNP). |
| OTI Annotation | This TrueClone is provided through our Custom Cloning Process that includes sub-cloning into OriGene's pCMV6 vector and full sequencing to provide a non-variant match to the expected reference without frameshifts, and is delivered as lyophilized plasmid DNA. |
| Product Components | The ORF clone is ion-exchange column purified and shipped in a 2D barcoded Matrix tube containing 10ug of transfection-ready, dried plasmid DNA (reconstitute with 100 ul of water). |
| Reconstitution | 1. Centrifuge at 5,000xg for 5min. 2. Carefully open the tube and add 100ul of sterile water to dissolve the DNA. 3. Close the tube and incubate for 10 minutes at room temperature. 4. Briefly vortex the tube and then do a quick spin (less than 5000xg) to concentrate the liquid at the bottom. 5. Store the suspended plasmid at -20°C. The DNA is stable for at least one year from date of shipping when stored at -20°C. |
| Reference Data | |
| RefSeq | NM_001557.2, NP_001548.1 |
| RefSeq Size | 2859 bp |
| RefSeq ORF | 1083 bp |
| Locus ID | 3579 |
| UniProt ID | P25025 |
| Domains | 7tm_1 |
| Protein Families | Druggable Genome, GPCR, Transmembrane |
| Protein Pathways | Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Endocytosis, Epithelial cell signaling in Helicobacter pylori infection |
| Gene Summary | The protein encoded by this gene is a member of the G-protein-coupled receptor family. This protein is a receptor for interleukin 8 (IL8). It binds to IL8 with high affinity, and transduces the signal through a G-protein activated second messenger system. This receptor also binds to chemokine (C-X-C motif) ligand 1 (CXCL1/MGSA), a protein with melanoma growth stimulating activity, and has been shown to be a major component required for serum-dependent melanoma cell growth. This receptor mediates neutrophil migration to sites of inflammation. The angiogenic effects of IL8 in intestinal microvascular endothelial cells are found to be mediated by this receptor. Knockout studies in mice suggested that this receptor controls the positioning of oligodendrocyte precursors in developing spinal cord by arresting their migration. This gene, IL8RA, a gene encoding another high affinity IL8 receptor, as well as IL8RBP, a pseudogene of IL8RB, form a gene cluster in a region mapped to chromosome 2q33-q36. Alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Nov 2009] Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments. |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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Targeting cellular heterogeneity with CXCR2 blockade for the treatment of therapy-resistant prostate cancer
,Li, Y;He, Y;Butler, W;Xu, L;Chang, Y;Lei, K;Zhang, H;Zhou, Y;Gao, AC;Zhang, Q;Taylor, DG;Cheng, D;Farber-Katz, S;Karam, R;Landrith, T;Li, B;Wu, S;Hsuan, V;Yang, Q;Hu, H;Chen, X;Flowers, M;McCall, SJ;Lee, JK;Smith, BA;Park, JW;Goldstein, AS;Witte, ON;Wang, Q;Rettig, MB;Armstrong, AJ;Cheng, Q;Huang, J;,
Sci Transl Med
,PubMed ID 31801883
[CXCR2]
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AUF1 and HuR Proteins Stabilize Interleukin-8 mRNA in Human Saliva
,V. Palanisamy, N.J. Park, J. Wang, and D.T. Wong,
J. Dent. Res., Aug 2008; 87: 772 - 776.
[CXCR2]
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