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NSMase2 (SMPD3) (NM_018667) Human Tagged ORF Clone Lentiviral Particle
CAT＃: RC218441L1V
- LentiORF®
-
Lenti ORF particles, SMPD3 (Myc-DDK tagged) - Human sphingomyelin phosphodiesterase 3, neutral membrane (neutral sphingomyelinase II) (SMPD3), 200ul, >10^7 TU/mL
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CNY 8,930.00
货期*
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规格
| Cited in 2 publications. |
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经常一起买 (3)
Specifications
| Product Data | |
| Product Name | NSMase2 (SMPD3) (NM_018667) Human Tagged ORF Clone Lentiviral Particle |
| Synonyms | NSMASE2 |
| Vector | pLenti-C-Myc-DDK |
| ACCN | NM_018667 |
| ORF Size | 1965 bp |
| Sequence Data |
The ORF insert of this clone is exactly the same as(RC218441).
|
| OTI Disclaimer | The molecular sequence of this clone aligns with the gene accession number as a point of reference only. However, individual transcript sequences of the same gene can differ through naturally occurring variations (e.g. polymorphisms), each with its own valid existence. This clone is substantially in agreement with the reference, but a complete review of all prevailing variants is recommended prior to use. More info |
| OTI Annotation | This clone was engineered to express the complete ORF with an expression tag. Expression varies depending on the nature of the gene. |
| Reference Data | |
| RefSeq | NM_018667.2, NP_061137.1 |
| RefSeq Size | 5284 bp |
| RefSeq ORF | 1968 bp |
| Locus ID | 55512 |
| Domains | Exo_endo_phos |
| Protein Families | Transmembrane |
| Protein Pathways | Metabolic pathways, Sphingolipid metabolism |
| MW | 70.9 kDa |
| Gene Summary | Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization.[UniProtKB/Swiss-Prot Function] |
Citations (2)
| The use of this cDNA Clones has been cited in the following citations: |
|---|
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DPTIP, a newly identified potent brain penetrant neutral sphingomyelinase 2 inhibitor, regulates astrocyte-peripheral immune communication following brain inflammation
,null,
Scientific Reports
,PubMed ID 30531925
[SMPD3]
|
|
Cambinol, a Novel Inhibitor of Neutral Sphingomyelinase 2 Shows Neuroprotective Properties
,null,
PLoS ONE
,PubMed ID 26010541
[SMPD3]
|
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