Human PAK4 activation kit by CRISPRa

CAT#: GA107018

PAK4 CRISPRa kit - CRISPR gene activation of human p21 (RAC1) activated kinase 4



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CNY 12,255.00


货期*
4周

规格
    • 1 kit

Product images

经常一起买 (3)
PAK4 mouse monoclonal antibody, clone OTI1C7 (formerly 1C7)
    • 100 ul

CNY 1,999.00
CNY 2,700.00


PAK4 (Myc-DDK-tagged)-Human p21 protein (Cdc42/Rac)-activated kinase 4 (PAK4), transcript variant 3
    • 10 ug

CNY 4,400.00
CNY 4,560.00


PAK4 mouse monoclonal antibody, clone OTI3C3 (formerly 3C3)
    • 30 ul

CNY 800.00

Specifications

Product Data
Format 3 gRNAs (5ug each), 1 scramble ctrl (10ug) and 1 enhancer vector (10ug)
Symbol PAK4
Locus ID 10298
Kit Components

GA107018G1, PAK4 gRNA vector 1 in pCas-Guide-GFP-CRISPRa

GA107018G2, PAK4 gRNA vector 2 in pCas-Guide-GFP-CRISPRa

GA107018G3, PAK4 gRNA vector 3 in pCas-Guide-GFP-CRISPRa

1 CRISPRa-Enhancer vector, SKU GE100056

1 CRISPRa scramble vector, SKU GE100077

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPRa SAM technology. The efficiency of the activation can be affected by many factors, including nucleosome occupancy status, chromatin structure and the gene expression level of the target, etc.
Reference Data
RefSeq NM_001014831, NM_001014832, NM_001014833, NM_001014834, NM_001014835, NM_005884
Synonyms p21 protein (Cdc42/Rac)-activated kinase 4; p21(CDKN1A)-activated kinase 4; p21-activated kinase 4; protein kinase related to S. cerevisiae STE20, effector for Cdc42Hs
Summary PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical effectors that link Rho GTPases to cytoskeleton reorganization and nuclear signaling. They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological activities. PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a mediator of filopodia formation and may play a role in the reorganization of the actin cytoskeleton. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

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