RTEL1 Human Gene Knockout Kit (CRISPR)

CAT#: KN214507LP

RTEL1 - human gene knockout kit via CRISPR, HDR mediated




 HDR-mediated knockout kit validation

  See Other Versions

CNY 12,260.00


货期*
6周

规格
    • 1 kit

Product images

经常一起买 (3)
pCAS-Scramble, pCas-Guide vector with a scrambled sequence as a negative control (10 µg)
    • 10 ug

CNY 3,710.00


Rabbit Polyclonal RTEL1 Antibody
    • 100 ul

CNY 5,381.00


Lenti ORF particles, RTEL1 (Myc-DDK tagged) - Human regulator of telomere elongation helicase 1 (RTEL1), transcript variant 2, 200ul, >10^7 TU/mL
    • 200 ul

CNY 21,565.00

Specifications

Product Data
Format 2 gRNA vectors, 1 Luciferase-Puro donor, 1 scramble control
Donor DNA Luciferase-Puro
Symbol RTEL1
Locus ID 51750
Kit Components

KN214507G1, RTEL1 gRNA vector 1 in pCas-Guide CRISPR vector

KN214507G2, RTEL1 gRNA vector 2 in pCas-Guide CRISPR vector

KN214507LP-D, donor DNA containing left and right homologous arms and Luciferase-Puro functional cassette.

pUC vector backbone in gray; Left arm sequence in blue; Luciferase-Puro in green; Right arm in violet

CTCCAGCCAG CCAGGAGGGC AGAGGGCTGG AGAGGCAGGG CCGGAGGTTC AGACCCTCCG CTCTGACGTT GCGCCTGGTG AGGCCGGGAG GGGTGCCGCT TGCCTCTTCA GCCCTCACGC TCTTGTGGAA GTCGCGGAAT TACTGCAGGC GGAACTTGCA GCACTGTGGG CGTCTTTTCC AGAGAAGGAC GGAGTTGTGG GGCGGGAGGA TAAGGCAAGG CCCAGCCACT TCGCATCTTC GCCCCGCCAG CTCCTCGAGA TGGGATATAC CAGGGTTGCT CTCCAACCCT CTCCGCAGGA GGGACTGATG GAAACGCCTG GGAAAGTAGC CCGGTACCCA CAAAGGCTGT CTACAAACAG AGTCTTACTG TCTTTCCCAG GTCTGTGCCA TAGGGATTCT CGAAGAGAAC AGCGTTGTGT CCCAGTGCAC ATGCTCGCAT CGCTTACCAG GAGTGCCCGA GACCCTAAGA TGTTCGGAGT GGTTTTTTCG CACAGACCCG AATAGCCTGC CCCTCAGCCA CGCTCTGTGC CCTTCTGAGA ACAGGCTGAT AGGTAGAGCA CAGGCCCCGA GGAAAGGACT GCGGGTGGGT GGAGCTTCAG CCAGGACGGG GTGTGCTTCC CTCTCCCGGC CCATTCCAGC CAGGCCCCTC CGGGCCAGAG GCAGCGTCTG TCATAAAAAG GGCTGGTGTT CCAGGTGGGG TCAGAGAGAG GATTGACAAG TAAAAACGAT CGTCCTTTGA AGGGGGCCGG CCCCTCCACA CCTGTGGGTA TTTCTCATCA GGCGGGACGA GAGACTGAGA AAATGAATAA GACACAGAGA CAAAGTATAG AGAGAAAAGT GGGCCCAGGG GACCGGCGCT CAGCATACAG AGGACCTGCA CCGGCACCAG TCTCTGAGTT TCCTCAGTAT TCATTAATTA CTATTTTCAC TATCTCAGCA AGAGGAATGC GGCAGGACAG CAAGGTGATA GTGGGGAGAA GGTCAGCAAG AAAACGTGAG CAAAGGAATC TGGGTCACAA ATAAGTTCAA GGGAAGGTAC TATGCCTGGA TGTGCACGTA GGCTAGTTTT ATGCTTTTCT CCACCCAAAC ATCTCGGTGG

GE100003, scramble sequence in pCas-Guide vector

Disclaimer These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq NM_001283009, NM_001283010, NM_016434, NM_032957
Synonyms C20orf41; DKCA4; DKCB5; NHL; RTEL
Summary This gene encodes a DNA helicase which functions in the stability, protection and elongation of telomeres and interacts with proteins in the shelterin complex known to protect telomeres during DNA replication. Mutations in this gene have been associated with dyskeratosis congenita and Hoyerall-Hreidarsson syndrome. Read-through transcription of this gene into the neighboring downstream gene, which encodes tumor necrosis factor receptor superfamily, member 6b, generates a non-coding transcript. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Sep 2013]
*Delivery time may vary from web posted schedule. Occasional delays may occur due to unforeseen complexities in the preparation of your product. International customers may expect an additional 1-2 weeks in shipping.

Documents

Other Versions

Customer Reviews 
Loading...