Riok2 Mouse Gene Knockout Kit (CRISPR)

Specifications

Product Data
Format	2 gRNA vectors, 1 mBFP-Neo donor, 1 scramble control
Donor DNA	mBFP-Neo
Symbol	Riok2
Locus ID	67045
Kit Components	KN314838G1, Riok2 gRNA vector 1 in pCas-Guide CRISPR vector KN314838G2, Riok2 gRNA vector 2 in pCas-Guide CRISPR vector KN314838BN-D, donor DNA containing left and right homologous arms and mBFP-Neo functional cassette. GE100003, scramble sequence in pCas-Guide vector
Disclaimer	These products are manufactured and supplied by OriGene under license from ERS. The kit is designed based on the best knowledge of CRISPR technology. The system has been functionally validated for knocking-in the cassette downstream the native promoter. The efficiency of the knock-out varies due to the nature of the biology and the complexity of the experimental process.
Reference Data
RefSeq	NM_025934
Synonyms	2010110K24Rik; 2410085M17Rik
Summary	Serine/threonine-protein kinase involved in the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Involved in export of the 40S pre-ribosome particles (pre-40S) from the nucleus to the cytoplasm. Its kinase activity is required for the release of NOB1, PNO1 and LTV1 from the late pre-40S and the processing of 18S-E pre-rRNA to the mature 18S rRNA. May regulate the timing of the metaphase-anaphase transition during mitotic progression, and its phosphorylation, may regulates this function.[UniProtKB/Swiss-Prot Function]

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