PKC zeta (PRKCZ) (NM_001033581) Human Mass Spec Standard

CAT#: PH300438

PRKCZ MS Standard C13 and N15-labeled recombinant protein (NP_001028753)



  View other "PKC zeta" proteins (7)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
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Transient overexpression lysate of protein kinase C, zeta (PRKCZ), transcript variant 1
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Specifications

Product Data
Description PRKCZ MS Standard C13 and N15-labeled recombinant protein (NP_001028753)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC200438
Predicted MW 67.7 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001028753
RefSeq Size 2147
RefSeq ORF 1776
Synonyms PKC-ZETA; PKC2
Locus ID 5590
Cytogenetics 1p36.33
Summary Protein kinase C (PKC) zeta is a member of the PKC family of serine/threonine kinases which are involved in a variety of cellular processes such as proliferation, differentiation and secretion. Unlike the classical PKC isoenzymes which are calcium-dependent, PKC zeta exhibits a kinase activity which is independent of calcium and diacylglycerol but not of phosphatidylserine. Furthermore, it is insensitive to typical PKC inhibitors and cannot be activated by phorbol ester. Unlike the classical PKC isoenzymes, it has only a single zinc finger module. These structural and biochemical properties indicate that the zeta subspecies is related to, but distinct from other isoenzymes of PKC. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome, Protein Kinase
Protein Pathways Chemokine signaling pathway, Endocytosis, Insulin signaling pathway, Tight junction, Type II diabetes mellitus
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