CCR4 NOT transcription complex subunit 3 (CNOT3) (NM_014516) Human Mass Spec Standard

CAT#: PH303795

CNOT3 MS Standard C13 and N15-labeled recombinant protein (NP_055331)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of CCR4-NOT transcription complex, subunit 3 (CNOT3)
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Specifications

Product Data
Description CNOT3 MS Standard C13 and N15-labeled recombinant protein (NP_055331)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC203795
Predicted MW 81.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_055331
RefSeq Size 2908
RefSeq ORF 2259
Synonyms IDDSADF; LENG2; NOT3; NOT3H
Locus ID 4849
Cytogenetics 19q13.42
Summary Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.[UniProtKB/Swiss-Prot Function]
Protein Families Transcription Factors
Protein Pathways RNA degradation
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