IL10RA (NM_001558) Human Mass Spec Standard

CAT#: PH307020

IL10RA MS Standard C13 and N15-labeled recombinant protein (NP_001549)



  View other "IL10RA" proteins (3)

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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description IL10RA MS Standard C13 and N15-labeled recombinant protein (NP_001549)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC207020
Predicted MW 62.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001549
RefSeq Size 3649
RefSeq ORF 1734
Synonyms CD210; CD210a; CDW210A; HIL-10R; IL-10R1; IL10R
Locus ID 3587
Cytogenetics 11q23.3
Summary The protein encoded by this gene is a receptor for interleukin 10. This protein is structurally related to interferon receptors. It has been shown to mediate the immunosuppressive signal of interleukin 10, and thus inhibits the synthesis of proinflammatory cytokines. This receptor is reported to promote survival of progenitor myeloid cells through the insulin receptor substrate-2/PI 3-kinase/AKT pathway. Activation of this receptor leads to tyrosine phosphorylation of JAK1 and TYK2 kinases. Two transcript variants, one protein-coding and the other not protein-coding, have been found for this gene. [provided by RefSeq, Jan 2009]
Protein Families Druggable Genome, Transmembrane
Protein Pathways Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway
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