IL23 (IL23A) (NM_016584) Human Mass Spec Standard

Specifications

Product Data
Description	IL23A MS Standard C13 and N15-labeled recombinant protein (NP_057668)
Species	Human
Expression Host	HEK293
Expression cDNA Clone or AA Sequence	RC209680
Predicted MW	20.8 kDa
Protein Sequence	Sequence Link (showhide) >RC209680 protein sequence Red=Cloning site Green=Tags(s) MLGSRAVMLLLLLPWTAQGRAVPGGSSPAWTQCQQLSQKLCTLAWSAHPLVGHMDLREEGDEETTNDVPH IQCGDGCDPQGLRDNSQFCLQRIHQGLIFYEKLLGSDIFTGEPSLLPDSPVGQLHASLLGLSQLLQPEGH HWETQQMPSLSPSQPWQRLLLRFKILRNLQAFVAVAARVFAHGAATLSP TRTRPLEQKLISEEDLAANDILDYKDDDDKV
Tag	C-Myc/DDK
Purity	> 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration	>0.05 µg/µL as determined by microplate BCA method
Labeling Method	Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer	25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq	NP_057668
RefSeq Size	1049
RefSeq ORF	567
Synonyms	IL-23; IL-23A; IL23P19; P19; SGRF
Locus ID	51561
Cytogenetics	12q13.3
Summary	This gene encodes a subunit of the heterodimeric cytokine interleukin 23 (IL23). IL23 is composed of this protein and the p40 subunit of interleukin 12 (IL12B). The receptor of IL23 is formed by the beta 1 subunit of IL12 (IL12RB1) and an IL23 specific subunit, IL23R. Both IL23 and IL12 can activate the transcription activator STAT4, and stimulate the production of interferon-gamma (IFNG). In contrast to IL12, which acts mainly on naive CD4(+) T cells, IL23 preferentially acts on memory CD4(+) T cells. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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