POLR3H (NM_001018050) Human Mass Spec Standard

CAT#: PH310633

POLR3H MS Standard C13 and N15-labeled recombinant protein (NP_001018060)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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经常一起买 (2)
POLR3H mouse monoclonal antibody,clone OTI4D8
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Transient overexpression lysate of polymerase (RNA) III (DNA directed) polypeptide H (22.9kD) (POLR3H), transcript variant 1
    • 100 ug

CNY 3,080.00

Specifications

Product Data
Description POLR3H MS Standard C13 and N15-labeled recombinant protein (NP_001018060)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC210633
Predicted MW 22.9 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_001018060
RefSeq Size 4492
RefSeq ORF 612
Synonyms C25; RPC8; RPC22.9
Locus ID 171568
Cytogenetics 22q13.2
Summary DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway (By similarity).[UniProtKB/Swiss-Prot Function]
Protein Families Transcription Factors
Protein Pathways Cytosolic DNA-sensing pathway, Metabolic pathways, Purine metabolism, Pyrimidine metabolism, RNA polymerase
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