PSMA (FOLH1) (NM_004476) Human Mass Spec Standard

CAT#: PH318310

FOLH1 MS Standard C13 and N15-labeled recombinant protein (NP_004467)



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CNY 19,520.00


货期*
4周

规格
    • 10 ug

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Specifications

Product Data
Description FOLH1 MS Standard C13 and N15-labeled recombinant protein (NP_004467)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC218310
Predicted MW 84.2 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_004467
RefSeq Size 2653
RefSeq ORF 2250
Synonyms FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA
Locus ID 2346
Cytogenetics 11p11.12
Summary This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq, Jul 2010]
Protein Families Druggable Genome, Protease, Transmembrane
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