Integrin beta 4 (ITGB4) (NM_000213) Human Mass Spec Standard

CAT#: PH320541

ITGB4 MS Standard C13 and N15-labeled recombinant protein (NP_000204)



  View other "Integrin beta 4" proteins (5)

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CNY 14,250.00


货期*
5周

规格
    • 10 ug

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经常一起买 (2)
Transient overexpression lysate of integrin, beta 4 (ITGB4), transcript variant 1
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    • 100 ul

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Specifications

Product Data
Description ITGB4 MS Standard C13 and N15-labeled recombinant protein (NP_000204)
Species Human
Expression Host HEK293
Expression cDNA Clone or AA Sequence RC220541
Predicted MW 202.12 kDa
Protein Sequence
Tag C-Myc/DDK
Purity > 80% as determined by SDS-PAGE and Coomassie blue staining
Concentration >0.05 µg/µL as determined by microplate BCA method
Labeling Method Labeled with [U- 13C6, 15N4]-L-Arginine and [U- 13C6, 15N2]-L-Lysine
Buffer 25 mM Tris-HCl, 100 mM glycine, pH 7.3
Reference Data
RefSeq NP_000204
RefSeq Size 5925
RefSeq ORF 5466
Synonyms CD104; GP150
Locus ID 3691
Cytogenetics 17q25.1
Summary Integrins are heterodimers comprised of alpha and beta subunits, that are noncovalently associated transmembrane glycoprotein receptors. Different combinations of alpha and beta polypeptides form complexes that vary in their ligand-binding specificities. Integrins mediate cell-matrix or cell-cell adhesion, and transduced signals that regulate gene expression and cell growth. This gene encodes the integrin beta 4 subunit, a receptor for the laminins. This subunit tends to associate with alpha 6 subunit and is likely to play a pivotal role in the biology of invasive carcinoma. Mutations in this gene are associated with epidermolysis bullosa with pyloric atresia. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein Families Druggable Genome
Protein Pathways Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, ECM-receptor interaction, Focal adhesion, Hypertrophic cardiomyopathy (HCM), Regulation of actin cytoskeleton
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