Collagen type II alpha 1 chain (Adult Knee Cartilage) Human Protein

Specifications

Product Data
Description	Collagen type II alpha 1 chain (Adult Knee Cartilage) human protein, 0.1 mg
Species	Human
Protein Source	Cartilage
Concentration	lot specific
Purity	>98% Chromatographically and immunologically pure.
Buffer	State: Liquid (sterile filtered) purified Ig fraction. Buffer System: 0.5M Acetic Acid containing 0.01% Sodium Azide as preservative.
Preparation	Liquid (sterile filtered) purified Ig fraction.
Applications	Suitable for use as a control or standard in indirect trapping ELISA for quantitation of antigen in serum using a standard curve, for Immunoprecipitation and for Western blotting
Protein Description	This protein has been prepared from adult human knee cartilage and is free from other collagens, human serum proteins and non-collagen extracellular matrix proteins. This product reacts with anti-Collagen Type II. Reaction with anti-Collagen I, III, IV, V or VI is negligible (typically less than 1% cross reactivity was detected by ELISA).
Storage	Store vial at 2-8°C prior to opening. This product is stable 2-8°C as an undiluted liquid. Dilute only prior to immediate use.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001835
Locus ID	1280
Cytogenetics	12q13.11
Synonyms	ANFH; AOM; COL11A3; SEDC; STL1
Summary	This gene encodes the alpha-1 chain of type II collagen, a fibrillar collagen found in cartilage and the vitreous humor of the eye. Mutations in this gene are associated with achondrogenesis, chondrodysplasia, early onset familial osteoarthritis, SED congenita, Langer-Saldino achondrogenesis, Kniest dysplasia, Stickler syndrome type I, and spondyloepimetaphyseal dysplasia Strudwick type. In addition, defects in processing chondrocalcin, a calcium binding protein that is the C-propeptide of this collagen molecule, are also associated with chondrodysplasia. There are two transcripts identified for this gene. [provided by RefSeq, Jul 2008]
Protein Pathways	ECM-receptor interaction, Focal adhesion

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