GADD153 / CHOP (1-169) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MAAESLPFSF GTLSSWELEA WYEDLQEVLS SDENGGTYVS PPGNEEEESK IFTTLDPASL AWLTEEEPEP AEVTSTSQSP HSPDSSQSSL AQEEEEEDQG RTRKRKQSGH SPARAGKQRM KEKEQENERK VAQLAEENER LKQEIERLTR EVEATRRALI DRMVNLHQA
Predicted MW	21 kDa
Concentration	lot specific
Purity	>95% > 90% by SDS-PAGE
Buffer	Presentation State: Purified State: Liquid Buffer System: 20 mM Tris pH 8.0, 20% Glycerol
Preparation	Liquid
Protein Description	Recombinant Human GADD153 (Growth arrest-and DNA damage-inducible gene 153), His-tagged
Note	NCBI Accession No: NP_004074
Storage	Store upon receipt (in aliquots) at -20 °C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_001181982
Locus ID	1649
UniProt ID	P35638
Cytogenetics	12q13.3
Synonyms	AltDDIT3; C/EBPzeta; CEBPZ; CHOP; CHOP-10; CHOP10; GADD153
Summary	This gene encodes a member of the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors. The protein functions as a dominant-negative inhibitor by forming heterodimers with other C/EBP members, such as C/EBP and LAP (liver activator protein), and preventing their DNA binding activity. The protein is implicated in adipogenesis and erythropoiesis, is activated by endoplasmic reticulum stress, and promotes apoptosis. Fusion of this gene and FUS on chromosome 16 or EWSR1 on chromosome 22 induced by translocation generates chimeric proteins in myxoid liposarcomas or Ewing sarcoma. Multiple alternatively spliced transcript variants encoding two isoforms with different length have been identified. [provided by RefSeq, Aug 2010]
Protein Families	Druggable Genome, Transcription Factors
Protein Pathways	MAPK signaling pathway

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