Dickkopf-1 (32-266, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	Hi-5 insect
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) ADPTLNSVLN SNAIKNLPPP LGGAAGHPGS AVSAAPGILY PGGNKYQTID NYQPYPCAED EECGTDEYCA SPTRGGDAGV QICLACRKRR KRCMRHAMCC PGNYCKNGIC VSSDQNHFRG EIEETITESF GNDHSTLDGY SRRTTLSSKM YHTKGQEGSV CLRSSDCASG LCCARHFWSK ICKPVLKEGQ VCTKHRRKGS HGLEIFQRCY CGEGLSCRIQ KDHHQASNSS RLHTCQRHSG RLVPRGSHHH HHH
Tag	His-tag
Predicted MW	27.8 kDa
Concentration	lot specific
Purity	>85% by SDS - PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: PBS (pH 7.4) containing 50% glycerol, 2 mM DTT, 2 mM EDTA, 0.1 mM PMSF
Preparation	Liquid purified protein
Protein Description	Recombinant Human Dkk-1 protein, fused to His-tag at C-terminus, was expressed ininsect cell using baculovirus expression system and purified by using conventional chromatography.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 1.0 EU per 1 µg of protein (determined by LAL method )
Reference Data
RefSeq	NP_036374
Locus ID	22943
UniProt ID	O94907, I1W660
Cytogenetics	10q21.1
Synonyms	DKK-1; SK
Summary	This gene encodes a member of the dickkopf family of proteins. Members of this family are secreted proteins characterized by two cysteine-rich domains that mediate protein-protein interactions. The encoded protein binds to the LRP6 co-receptor and inhibits beta-catenin-dependent Wnt signaling. This gene plays a role in embryonic development and may be important in bone formation in adults. Elevated expression of this gene has been observed in numerous human cancers and this protein may promote proliferation, invasion and growth in cancer cell lines. [provided by RefSeq, Sep 2017]
Protein Families	Adult stem cells, Cancer stem cells, Druggable Genome, ES Cell Differentiation/IPS, Secreted Protein, Stem cell relevant signaling - Wnt Signaling pathway
Protein Pathways	Wnt signaling pathway

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