MIP1 alpha / CCL3 (24-92, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MSLAADTPTA CCFSYTSRQI PQNFIADYFE TSSQCSKPGV IFLTKRSRQV CADPSEEWVQ KYVSDLELSA
Tag	His-tag
Purity	>90%
Buffer	Presentation State: Purified State: Liquid purified peptide Buffer System: 10 mM Sodium Citrate (pH 3.5) containing 10% glycerol
Preparation	Liquid purified peptide
Protein Description	Recombinant human CCL3, fused to His-tag at N-terminus, was expressed in E.coli and purifed by conventional chromatography, after refolding of the isolated inclusion bodies in a renaturation buffer.
Storage	Store undiluted at 2-8°C for up to two weeks or (in aliquots) at -20°C or -70°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 1.0 EU per 1 μg of protein (determined by LAL method)
Reference Data
RefSeq	NP_002974
Locus ID	6348
UniProt ID	P10147, A0N0R1
Cytogenetics	17q12
Synonyms	G0S19-1; LD78ALPHA; MIP-1-alpha; MIP1A; SCYA3
Summary	This locus represents a small inducible cytokine. The encoded protein, also known as macrophage inflammatory protein 1 alpha, plays a role in inflammatory responses through binding to the receptors CCR1, CCR4 and CCR5. Polymorphisms at this locus may be associated with both resistance and susceptibility to infection by human immunodeficiency virus type 1.[provided by RefSeq, Sep 2010]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Chemokine signaling pathway, Cytokine-cytokine receptor interaction, Toll-like receptor signaling pathway

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