Gremlin-1 / GREM1 Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MKKKGSQGAI PPPDKAQHND SEQTQSPQQP GSRNRGRGQG RGTAMPGEEV LESSQEALHV TERKYLKRDW CKTQPLKQTI HEEGCNSRTI INRFCYGQCN SFYIPRHIRK EEGSFQSCSF CKPKKFTMMV TLNCPELQPP TKKKRVTRVK QCRCISIDLD
Predicted MW	18.4 kDa
Purity	>95% by SDS-PAGE and Silver staining
Buffer	Presentation State: Purified State: Lyophilized protein Buffer System: 50 mM Acetic Acid Stabilizer: None
Preparation	Lyophilized protein
Protein Description	Recombinant Human Gremlin-1, aa. 161.  Result by N-terminal sequencing: MKKKGSQGAI
Note	Protein RefSeq: NP_001178252.1 mRNA RefSeq: NM_013372
Storage	Store lyophilized at 2-8°C for 6 months or at -20°C long term. After reconstitution store the antibody undiluted at 2-8°C for one month  or (in aliquots) at -20°C long term. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 0.1 ng per μg of Grem1
Reference Data
RefSeq	NP_001178251
Locus ID	26585
UniProt ID	B3KTR9
Cytogenetics	15q13.3
Synonyms	C15DUPq; CKTSF1B1; CRAC1; CRCS4; DAND2; DRM; DUP15q; GREMLIN; HMPS; HMPS1; IHG-2; MPSH; PIG2
Summary	This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2010]
Protein Families	ES Cell Differentiation/IPS, Secreted Protein

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