STK11 (1-433, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MGSSHHHHHH SSGLVPRGSH MGSMEVVDPQ QLGMFTEGEL MSVGMDTFIH RIDSTEVIYQ PRRKRAKLIG KYLMGDLLGE GSYGKVKEVL DSETLCRRAV KILKKKKLRR IPNGEANVKK EIQLLRRLRH KNVIQLVDVL YNEEKQKMYM VMEYCVCGMQ EMLDSVPEKR FPVCQAHGYF CQLIDGLEYL HSQGIVHKDI KPGNLLLTTG GTLKISDLGV AEALHPFAAD DTCRTSQGSP AFQPPEIANG LDTFSGFKVD IWSAGVTLYN ITTGLYPFEG DNIYKLFENI GKGSYAIPGD CGPPLSDLLK GMLEYEPAKR FSIRQIRQHS WFRKKHPPAE APVPIPPSPD TKDRWRSMTV VPYLEDLHGA DEDEDLFDIE DDIIYTQDFT VPGQVPEEEA SHNGQRRGLP KAVCMNGTEA AQLSTKSRAE GRAPNPARKA CSASSKIRRL SACKQQ
Tag	His-tag
Predicted MW	51.0 kDa
Concentration	lot specific
Purity	>85% by SDS - PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: 20 mM Tris-HCl buffer (pH 8.0) containing 10% Glycerol.
Preparation	Liquid purified protein
Protein Description	Recombinant human STK11 protein, fused to His-tag at N-terminus, was expressed in E.coli.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Reference Data
RefSeq	NP_000446
Locus ID	6794
UniProt ID	Q15831, A0A0S2Z4D1
Cytogenetics	19p13.3
Synonyms	hLKB1; LKB1; PJS
Summary	This gene, which encodes a member of the serine/threonine kinase family, regulates cell polarity and functions as a tumor suppressor. Mutations in this gene have been associated with Peutz-Jeghers syndrome, an autosomal dominant disorder characterized by the growth of polyps in the gastrointestinal tract, pigmented macules on the skin and mouth, and other neoplasms. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Protein Kinase
Protein Pathways	Adipocytokine signaling pathway, mTOR signaling pathway

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