Interleukin-9 / IL9 (1-144, His-tag) Human Protein

Specifications

Product Data
Species	Human
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MLLAMVLTSA LLLCSVAGQG CPTLAGILDI NFLINKMQED PASKCHCSAN VTSCLCLGIP SDNCTRPCFS ERLSQMTNTT MQTRYPLIFS RVKKSVEVLK NNKCPYFSCE QPCNQTTAGN ALTFLKSLLE IFQKEKMRGM RGKIHHHHHH Red : Signal peptide
Tag	His-tag
Predicted MW	14.5 kDa
Concentration	lot specific
Purity	>85% by SDS – PAGE
Buffer	Presentation State: Purified State: Liquid purified protein Buffer System: Phosphate buffer saline (pH 7.4) containing 10% glycerol.
Preparation	Liquid purified protein
Protein Description	Recombinant human IL9, fused to His-tag at C-terminus, was expressed in Sf9 and purified by using conventional chromatography techniques.
Storage	Store undiluted at 2-8°C for one week or (in aliquots) at -20°C to -80°C for longer. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch.
Endotoxin	< 1.0 Eu per 1 microgram of protein (determined by LAL method)
Reference Data
RefSeq	NP_000581
Locus ID	3578
UniProt ID	P15248
Cytogenetics	5q31.1
Synonyms	HP40; IL-9; P40
Summary	The protein encoded by this gene is a cytokine that acts as a regulator of a variety of hematopoietic cells. This cytokine stimulates cell proliferation and prevents apoptosis. It functions through the interleukin 9 receptor (IL9R), which activates different signal transducer and activator (STAT) proteins and thus connects this cytokine to various biological processes. The gene encoding this cytokine has been identified as a candidate gene for asthma. Genetic studies on a mouse model of asthma demonstrated that this cytokine is a determining factor in the pathogenesis of bronchial hyperresponsiveness. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Secreted Protein
Protein Pathways	Asthma, Cytokine-cytokine receptor interaction, Jak-STAT signaling pathway

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