Hepatitis B Core Antigen / HBcAg (1-144) (ayw) Protein

Specifications

Product Data
Expression Host	E. coli
Concentration	lot specific
Purity	95% pure by SDS-PAGE
Buffer	Presentation State: Purified State: Liquid purified fraction Buffer System: 7.5 mM Phosphate buffer, 75 mM NaCl, pH 7.2 containing 50% Glycerol without preservatives
Preparation	Liquid purified fraction
Protein Description	HBV core antigen (HBcAg) recombinant. Amino acids 1-144 of HBV core antigen, 14 kDa. Deleted DNA binding domain. Cloned from HBV 320 genome. Does not contain fusion partner.
Storage	Store the antigen at 2-8°C for one month or (in aliquots) at -20°C for longer. Avoid multiple freeze/thaw cycles.
Stability	Shelf life: one year from despatch.
Reference Data
Summary	Hepatitis B Virus Core Antigen (HBcAg) is part of the infectious virion containing an inner "core particle" enclosing the viral genome. The icosahedral core particle contains 180 or 240 copies of the core protein. HBcAg is one of the three major clinical antigens of hepatitis B virus but disappears early in the course of infection. The hepatitis B virus core antigen (HBcAg) is a highly immunogenic subviral particle and functions as both a T-cell-dependent and a T-cell-independent antigen. Therefore, HBcAg may be a promising candidate target for therapeutic vaccine control of chronic HBV infection.

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