KITLG / SCF Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Predicted MW	18.5 kDa
Purity	>98% > 98% by RP-HPLC, Anion-exchange FPLC, Silver stain
Buffer	Presentation State: Purified State: Lyophilized without stabilizer Buffer System: 10 mM acetic acid
Preparation	Lyophilized without stabilizer
Protein Description	Recombinant Human SCF
Note	Centrifuge vials before opening!
Storage	Prior and following reconstitution store (in aliquots) at 2 - 8 °C for up to two weeks or -20 °C for longer. For long term storage add a carrier protein (0.1 % HAS or BSA). Avoid repeated freezing and thawing.
Stability	Shelf life: One year from despatch.
Bioactivity	Biological: Recombinant human SCF is fully biologically active when compared to standards. The ED50 determined by the dose-dependent stimulation of human TF-1 cells is < 2.0 ng/ml. Specific: 1 x 10e5 units/mg
Endotoxin	< 0.1 ng per µg (IEU/µg) of rh SCF
Reference Data
RefSeq	NP_000890
Locus ID	4254
UniProt ID	P21583, A0A024RBC0
Cytogenetics	12q21.32
Synonyms	DCUA; DFNA69; FPH2; FPHH; Kitl; KL-1; MGF; SCF; SF; SHEP7; SLF
Summary	This gene encodes the ligand of the tyrosine-kinase receptor encoded by the KIT locus. This ligand is a pleiotropic factor that acts in utero in germ cell and neural cell development, and hematopoiesis, all believed to reflect a role in cell migration. In adults, it functions pleiotropically, while mostly noted for its continued requirement in hematopoiesis. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Protein Families	Druggable Genome, Transmembrane
Protein Pathways	Cytokine-cytokine receptor interaction, Hematopoietic cell lineage, Melanogenesis, Pathways in cancer

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