Alpha-Synuclein / SNCA (1-140) Human Protein

Specifications

Product Data
Species	Human
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSKTKEGVVH GVATVAEKTK EQVTNVGGAV VTGVTAVAQK TVEGAGSIAA ATGFVKKDQL GKNEEGAPQE GILEDMPVDP DNEAYEMPSE EGYQDYEPEA
Predicted MW	14.46 kDa
Purity	>95%
Buffer	Presentation State: Purified State: Lyophilized from a 0.2 um filtered solution Buffer System: 20 mM Tris-HCl buffer (pH 7.5), 100 mM NaCl, 1 mM MgCl2
Preparation	Lyophilized from a 0.2 um filtered solution
Protein Description	Purified human recombinant alpha-Synuclein (amino acids 1-140).
Storage	Upon receipt, store it immediately at 2-8°C for up to one month. For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing.
Stability	Shelf life: one year from despatch
Endotoxin	< 1.0 EU per 1 ug of protein (determined by LAL method)
Reference Data
RefSeq	NP_000336
Locus ID	6622
UniProt ID	P37840
Cytogenetics	4q22.1
Synonyms	NACP; PARK1; PARK4; PD1
Summary	Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease. Alternatively spliced transcripts encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2016]
Protein Families	Druggable Genome
Protein Pathways	Alzheimer's disease, Parkinson's disease

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