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Lamin A (LMNA) (NM_170707) Human Recombinant Protein
CAT＃: TP304970
Recombinant protein of human lamin A/C (LMNA), transcript variant 1, 20 µg
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Specifications
| Product Data | |
| Species | Human |
| Expression Host | HEK293T |
| Expression cDNA Clone or AA Sequence |
>RC204970 protein sequence
Red=Cloning site Green=Tags(s) METPSQRRATRSGAQASSTPLSPTRITRLQEKEDLQELNDRLAVYIDRVRSLETENAGLRLRITESEEVV SREVSGIKAAYEAELGDARKTLDSVAKERARLQLELSKVREEFKELKARNTKKEGDLIAAQARLKDLEAL LNSKEAALSTALSEKRTLEGELHDLRGQVAKLEAALGEAKKQLQDEMLRRVDAENRLQTMKEELDFQKNI YSEELRETKRRHETRLVEIDNGKQREFESRLADALQELRAQHEDQVEQYKKELEKTYSAKLDNARQSAER NSNLVGAAHEELQQSRIRIDSLSAQLSQLQKQLAAKEAKLRDLEDSLARERDTSRRLLAEKEREMAEMRA RMQQQLDEYQELLDIKLALDMEIHAYRKLLEGEEERLRLSPSPTSQRSRGRASSHSSQTQGGGSVTKKRK LESTESRSSFSQHARTSGRVAVEEVDEEGKFVRLRNKSNEDQSMGNWQIKRQNGDDPLLTYRFPPKFTLK AGQVVTIWAAGAGATHSPPTDLVWKAQNTWGCGNSLRTALINSTGEEVAMRKLVRSVTVVEDDEDEDGDD LLHHHHGSHCSSSGDPAEYNLRSRTVLCGTCGQPADKASASGSGAQVGGPISSGSSASSVTVTRSYRSVG GSGGGSFGDNLVTRSYLLGNSSPRTQSPQNCSIM TRTRPLEQKLISEEDLAANDILDYKDDDDKV |
| Tag | C-Myc/DDK |
| Predicted MW | 74 kDa |
| Concentration | >0.1 µg/µL as determined by microplate BCA method |
| Purity | > 80% as determined by SDS-PAGE and Coomassie blue staining |
| Buffer | 25 mM Tris-HCl, 100 mM glycine, pH 7.3, 10% glycerol |
| Preparation | Recombinant protein was captured through anti-DDK affinity column followed by conventional chromatography steps. |
| Note | For testing in cell culture applications, please filter before use. Note that you may experience some loss of protein during the filtration process. |
| Storage | Store at -80°C. |
| Stability | Stable for 12 months from the date of receipt of the product under proper storage and handling conditions. Avoid repeated freeze-thaw cycles. |
| Reference Data | |
| RefSeq | NP_733821 |
| Locus ID | 4000 |
| UniProt ID | P02545, A0A384MQX1 |
| Refseq Size | 3239 |
| Cytogenetics | 1q22 |
| Refseq ORF | 1992 |
| Synonyms | CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; PRO1 |
| Summary | The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012] |
| Protein Families | Druggable Genome |
| Protein Pathways | Arrhythmogenic right ventricular cardiomyopathy (ARVC), Dilated cardiomyopathy, Hypertrophic cardiomyopathy (HCM) |
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Other Versions
| SKU | Description | Size | Price |
|---|---|---|---|
| LC406886 | LMNA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LC406887 | LMNA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 1,470.00 |
|
| LC417216 | LMNA HEK293T cell transient overexpression lysate (as WB positive control) |
CNY 900.00 |
|
| LY406886 | Transient overexpression lysate of lamin A/C (LMNA), transcript variant 1 |
CNY 3,080.00 |
|
| LY406887 | Transient overexpression lysate of lamin A/C (LMNA), transcript variant 3 |
CNY 4,840.00 |
|
| LY417216 | Transient overexpression lysate of lamin A/C (LMNA), transcript variant 2 |
CNY 3,080.00 |
|
| PH301809 | LMNA MS Standard C13 and N15-labeled recombinant protein (NP_005563) |
CNY 19,520.00 |
|
| PH304970 | LMNA MS Standard C13 and N15-labeled recombinant protein (NP_733821) |
CNY 19,520.00 |
|
| TP301809 | Recombinant protein of human lamin A/C (LMNA), transcript variant 2, 20 µg |
CNY 2,900.00 |
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