Il33 (NM_133775) Mouse Recombinant Protein

Specifications

Product Data
Species	Mouse
Expression Host	E. coli
Expression cDNA Clone or AA Sequence	Protein Sequence (showhide) Mouse IL-33, the region of Ser109-Ile266, from gene Accession# NM_133775
Tag	Tag Free
Predicted MW	17.6 kDa
Concentration	lot specific
Purity	>98%, as determined by Coomassie stained SDS-PAGE.
Buffer	20 mM HEPES, 150 mM NaCl, pH 7.2, 10 mM TCEP
Storage	Store at -80°C.
Stability	Unopened vial can be stored between 2°C and 8°C for up to 2 weeks, at -20°C for up to 6 months, or at -70°C or below until the expiration date. Aliquots can be stored between 2°C and 8°C for up to one week and stored at -20°C or colder for up to 3 months. Avoid repeated freeze/thaw cycles.
Endotoxin	Less than 0.1 EU/µg (<0.01 ng/µg) protein as determined by the LAL method
Reference Data
RefSeq	NP_598536
Locus ID	77125
UniProt ID	Q8BVZ5
Refseq Size	2534
Cytogenetics	19 C1
Refseq ORF	798
Synonyms	9230117N10Rik; Il-33; Il1f11; NF-HEV
Summary	Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells. Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury.[UniProtKB/Swiss-Prot Function]

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